1-ethyl-5-[2-(trimethylsilyl)ethynyl]-1H-pyrazole CAS 1707563-64-1
| CAS No. | 1707563-64-1 |
| Molecular Formula | C10H16N2Si |
| Molecular Weight | 192.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-ethyl-5-[2-(trimethylsilyl)ethynyl]-1H-pyrazole (C10H16N2Si) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 1-ethyl-5-[2-(trimethylsilyl)ethynyl]-1H-pyrazole (CAS 1707563-64-1), a certified reference material (molecular formula C10H16N2Si, MW 192.33 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16N2Si |
| Molecular Weight | 192.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 2 |
Related ethyl Standards
- 1-(Trimethylsilyl)-4-n-propylbenzene (CAS 81631-65-4)
- 5-[2-(Trimethylsilyl)ethynyl]furan-2-carbaldehyde (CAS 815609-95-1)
- 2-(Trimethylsilyl)-1,3-dithiane (CAS 13411-42-2)
- 3-((Trimethylsilyl)ethynyl)pyrazin-2-amine (CAS 1005349-12-1)
- 4-[2-(Trimethylsilyl)ethynyl]pyrimidin-2-amine (CAS 1214264-40-0)
- 5-((Trimethylsilyl)ethynyl)pyridazin-4-amine (CAS 1333319-58-6)
- 1-(Trimethylsilyl)-1H-benzo[d][1,2,3]triazole (CAS 43183-36-4)
- 5-((Trimethylsilyl)ethynyl)pyrimidin-2-amine (CAS 857265-75-9)
Recommended Standards
- 2-(Dimethyl(phenyl)silyl)prop-2-en-1-ol (CAS 101844-22-8)
- 2,2-Dimethyl-3,6,9-trioxa-2-siladecane (CAS 62199-57-9)
- Sulphinylbis(Diethylamide) (CAS 33641-61-1)
- 5-(Isopropylthio)-1,3,4-thiadiazole-2-thiol (CAS 62868-67-1)
- 5-Oxaspiro[2.4]heptan-1-amine (CAS 1514737-94-0)
- (S)-1-(2-Aminoethyl)-N-isopropyl-N-methylpyrrolidin-3-amine (CAS 1354010-39-1)
- Methyl 2-bromothiophene-3-carboxylate (CAS 76360-43-5)
- 2-(Benzyloxy)-N-[2-(1-naphthyl)ethyl]aniline (CAS 1040690-00-3)
- Nevirapine 3-Ethenyl (CAS 284686-22-2)
- 2-Hydroxy-6-(1-piperidinylsulfonyl)quinoline (CAS 891900-49-5)
- ethyl 3-(difluoromethyl)-1H-pyrazole-4-carboxylate (CAS 151733-96-9)
- [5-(piperidine-1-sulfonyl)thiophen-2-yl]methanamine hydrochloride (CAS 1049741-22-1)
- Methyl 3-(4-(difluoromethyl)-2-ethyl-3-methyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate (CAS 1018165-62-2)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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