7-(3-Fluorobenzyl)-[1,2,4]triazolo[4,3-a]pyrazine-3,8(2H,7H)-dione CAS 1708178-72-6
| CAS No. | 1708178-72-6 |
| Molecular Formula | C12H9FN4O2 |
| Molecular Weight | 260.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
7-(3-Fluorobenzyl)-[1,2,4]triazolo[4,3-a]pyrazine-3,8(2H,7H)-dione (CAS 1708178-72-6), molecular formula C12H9FN4O2 and molecular weight 260.22 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-(3-Fluorobenzyl)-[1,2,4]triazolo[4,3-a]pyrazine-3,8(2H,7H)-dione (C12H9FN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 7-(3-Fluorobenzyl)-[1,2,4]triazolo[4,3-a]pyrazine-3,8(2H,7H)-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9FN4O2 |
| Molecular Weight | 260.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Fluorobenzyl Standards
- 7-(2-Fluorobenzyl)-[1,2,4]triazolo[4,3-a]pyrazine-3,8(2H,7H)-dione (CAS 1713713-91-7)
- 2-(4-((4-Fluorobenzyl)oxy)phenyl)acetic acid (CAS 115882-26-3)
- 2-(3-((4-Fluorobenzyl)oxy)phenyl)acetic acid (CAS 125721-49-5)
- 2-((2-Fluorobenzyl)oxy)-3-methoxybenzaldehyde (CAS 588687-34-7)
- 2-((2-Fluorobenzyl)oxy)-5-methoxybenzaldehyde (CAS 831188-46-6)
- 2-((3-Fluorobenzyl)oxy)-3-methoxybenzaldehyde (CAS 588696-81-5)
- 2-((4-Fluorobenzyl)oxy)-3-methoxybenzaldehyde (CAS 384860-70-2)
- 2-((4-Fluorobenzyl)oxy)-5-methoxybenzaldehyde (CAS 934533-06-9)
Recommended Standards
- 1-((6-Fluoroimidazo[1,2-a]pyridin-2-yl)methyl)-1H-pyrazole-3-carboxylic acid (CAS 1707594-89-5)
- 1-((6-Fluoroimidazo[1,2-a]pyridin-2-yl)methyl)-1H-imidazole-4-carboxylic acid (CAS 1708370-59-5)
- N-(3-FLuorophenyl)-4-nitrobenzamide (CAS 167565-78-8)
- 3-(Difluoromethoxy)-5-(1H-pyrazol-1-yl)thiophene-2-carboxylic acid (CAS 1710202-46-2)
- rel-(1R,2S)-2-(But-3-en-1-yl)-1-methylcyclopentanol (CAS 1438268-15-5)
- 2-Amino-2-(3-ethoxy-4-hydroxyphenyl)acetic acid (CAS 54172-60-0)
- Isoquinolin-1-ylmethanamine hydrochloride (CAS 1177303-46-6)
- Rivaroxaban impurity 166 (CAS CATO-C4X-1090166)
- 2,4-Dimethoxy-6-hydroxybenzaldehyde; 4,6-Dimethoxy-2-hydroxybenzaldehyde 708-76-9 AB1002225 (CAS 708-76-9)
- (1S,4s)-4-(trifluoromethoxy)cyclohexan-1-amine (CAS 2231664-77-8)
- 2-(methoxy-d3)-5-nitropyridine (CAS 1809629-44-4)
- 1-(tert-Butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid (CAS 221141-79-3)
- 1-(Tetrahydro-2h-pyran-4-yl)-1h-1,2,3-triazol-4-amine (CAS 1443292-43-0)
- Semaglutide-d15 (CAS 910463-68-2(non-labelled))
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