Ethyl 6-(4-chlorophenyl)-2-(difluoromethyl)nicotinate CAS 1708208-56-3
| CAS No. | 1708208-56-3 |
| Molecular Formula | C15H12ClF2NO2 |
| Molecular Weight | 311.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 6-(4-chlorophenyl)-2-(difluoromethyl)nicotinate (CAS 1708208-56-3) is a high-purity analytical reference standard with the molecular formula C15H12ClF2NO2 and a molecular weight of 311.71 g/mol.
Structurally, Ethyl 6-(4-chlorophenyl)-2-(difluoromethyl)nicotinate (C15H12ClF2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 311.71 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12ClF2NO2 |
| Molecular Weight | 311.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Methyl 1-(2-(4-chlorophenyl)-2-hydroxyethyl)-5-(hydroxymethyl)-1H-1,2,3-triazole-4-carboxylate (CAS 1351772-52-5)
- 1-(4-Chlorophenyl)imidazo[2,1-b]quinazoline-2,5(1H,3H)-dione (CAS 62707-35-1)
- 2-(4-Chlorophenyl)-8-methyl-6H-chromeno[8,7-d]oxazol-6-one (CAS 36771-42-3)
- Methyl 2-((4-chlorophenyl)carbamoyl)-6-oxohexahydropyridazine-4-carboxylate (CAS 339096-86-5)
- 5-(2-Chlorophenyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 439111-04-3)
- 5-(3-Chlorophenyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 439111-02-1)
- (2E)-3-(3-Chlorophenyl)-2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-1,2,4-triazol-3-yl}prop-2-enenitrile (CAS 1164520-60-8)
- 3-(4-Chlorophenyl)-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-3-yl]acrylonitrile (CAS 1164552-75-3)
Recommended Standards
- Trelagliptin Impurity 31 (CAS CATO-C4X-104631)
- 2-(4-Chloro-2-methylphenoxy)-2,2-difluoro-N-phenylacetamide (CAS 339010-92-3)
- 7-Nitrodibenzo[b,d]furan-2-sulfonyl chloride (CAS 98045-13-7)
- Tizanidine Nitroso Impurity 14 (CAS CATO-C4X-144514)
- 5-Chloro-2-(3-fluorophenoxy)pyridine (CAS 1495131-49-1)
- Risperidone RC 2 (CAS 25519-77-1)
- 2-(Benzyloxy)-3-fluoro-4-methylbenzoic acid (CAS 2635937-35-6)
- 2-{[(4-methylphenyl)methyl]sulfanyl}-4,5-diphenyl-1-(prop-2-yn-1-yl)-1H-imidazole (CAS 339278-01-2)
- Paricalcitol Impurity 24 (CAS CATO-C4X-138724)
- 2-Bromo-4-methylbenzyl alcohol (CAS 824-53-3)
- 5-Ethynyloctahydro-1h-4,7-methanoinden-5-ol (CAS 13380-92-2)
- 2,7-Naphthalenedicarboxylic acid, 97% (CAS 2089-89-6)
- 1,4-bis[4-(11-acryloyloxyundecyloxy)benzoyloxy]-2-methylbenzene 215304-94-2 (CAS 215304-94-2)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com