2-(3-Methylphenyl)-1,3-thiazole-4-carboxylic acid CAS 17229-00-4
| CAS No. | 17229-00-4 |
| Molecular Formula | C11H9NO2S |
| Molecular Weight | 219.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(3-Methylphenyl)-1,3-thiazole-4-carboxylic acid (CAS 17229-00-4), molecular formula C11H9NO2S and molecular weight 219.26 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3-Methylphenyl)-1,3-thiazole-4-carboxylic acid (C11H9NO2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9NO2S |
| Molecular Weight | 219.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methylphenyl Standards
- 2-(2-methylphenyl)-1,3-thiazole-4-carboxylic acid (CAS 115311-25-6)
- 4-(4-Methylphenyl)-2-thiazolecarboxylic acid (CAS 123971-35-7)
- 3-(2-Methylphenyl)-1,2-thiazole-4-carboxylic acid (CAS 67048-49-1)
- 3-(3-Methylphenyl)-1,2-thiazole-4-carboxylic acid (CAS 67113-93-3)
- 3-(4-Methylphenyl)-1,2-thiazole-4-carboxylic acid (CAS 67049-13-2)
- 6-(4-Methylphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2h)-one (CAS 27623-05-8)
- 5-Methyl-3-(4-methylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 1326815-45-5)
- 1-(3-Methylphenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 56617-45-9)
Recommended Standards
- 2-(p-Tolyl)thiazole-4-carboxylic Acid (CAS 17228-99-8)
- 2-(4-Nitrobenzyl)thiophene (CAS 172508-14-4)
- 3-((1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino)acrylic acid (CAS 1704326-61-3)
- Methyl 2-phenyl-1,3-thiazole-5-carboxylate (CAS 172678-68-1)
- 7-(Aminomethyl)-5-chloroquinolin-8-ol dihydrochloride (CAS 66233-86-1)
- 6-Methyl-8-nitroquinolin-4-ol (CAS 190139-69-6)
- N-Isobutyl-5-methyl-1,3,4-thiadiazol-2-amine (CAS 554412-14-5)
- 5-Chloro-N-isopropyl-1-methyl-1H-pyrazole-4-carboxamide (CAS 648427-00-3)
- 5-(Trifluoromethyl)-1-[5-(trifluoromethyl)pyridin-2-yl]-1h-pyrazole-4-carboxylic acid (CAS 1013794-64-3)
- 6-Methyl-1H-indazol-7-amine (CAS 221681-91-0)
- N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)-4-(trifluoromethyl)benzamide (CAS 667887-29-8)
- 4-Chloro-2-(difluoromethyl)-3,5-diiodopyridine (CAS 1806826-38-9)
- (3-Chloro-5-(trifluoromethoxy)phenyl)methanol (CAS 433926-47-7)
- Palmitoyl Tripeptide-8 TFA salt (CAS 936544-53-5)
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