Umeclidinium impurity 22 CAS 17229-17-3
| CAS No. | 17229-17-3 |
| Molecular Formula | C9H11ClO |
| Molecular Weight | 170.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Umeclidinium impurity 22 is closely related to a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Umeclidinium impurity 22 (CAS 17229-17-3, C9H11ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Umeclidinium impurity 22 (C9H11ClO) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Umeclidinium impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO |
| Molecular Weight | 170.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related Umeclidinium Standards
- Umeclidinium impurity 24 (CAS 51069-26-2)
- Umeclidinium Bromide Impurity 25 (CAS 119102-52-2)
- Umeclidinium Impurity 1 (CAS 1509910-91-1)
- Umeclidinium impurity 25 (CAS 22766-68-3)
- Umeclidinium Impurity 8 (CAS 55022-88-3)
- Umeclidinium impurity 23 (CAS 622-08-2)
- Umeclidinium Impurity 16 (CAS 939900-20-6)
- Umeclidinium impurity 26 (CAS 1248400-28-3)
Recommended Standards
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- Dapoxetine Impurity 37 (CAS 100306-34-1)
- Cefuroxime Sodium EP Impurity I (CAS 39684-61-2)
- Belumosudil Impurity 33 (CAS 2121561-37-1)
- Orbifloxacin EP Impurity C (CAS 126457-99-6)
- (E)-2-Benzylidene-1-methylindolin-3-one (CAS 38072-58-1)
- 4-Amino-7-bromoisoindolin-1-one (CAS 866767-08-0)
- Methyl 3-(aminomethyl)cyclobutane-1-carboxylate (CAS 1631027-18-3)
- 1,1,1-Triethyl-3,3,3-trimethyldisiloxane (CAS 2652-41-7)
- 3-(tert-Butyl)-5-fluorobenzoic acid (CAS 1000341-38-7)
- 4-cyclopropyl-6-methyl-1,4-diazepan-2-one (CAS 1803599-59-8)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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