4-(Trifluoromethyl)nicotinohydrazide CAS 175204-84-9
| CAS No. | 175204-84-9 |
| Molecular Formula | C7H6F3N3O |
| Molecular Weight | 205.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 205.14 g/mol gives 4-(Trifluoromethyl)nicotinohydrazide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-(Trifluoromethyl)nicotinohydrazide (CAS 175204-84-9) is a high-purity analytical reference standard with the molecular formula C7H6F3N3O and a molecular weight of 205.14 g/mol.
The molecular framework of 4-(Trifluoromethyl)nicotinohydrazide (C7H6F3N3O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(Trifluoromethyl)nicotinohydrazide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H6F3N3O |
| Molecular Weight | 205.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 5-(Trifluoromethyl)-2-pyridinecarbohydrazide (CAS 1046156-31-3)
- 3-[5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]propanenitrile (CAS 1099669-96-1)
- 2-(Trifluoromethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (CAS 1196153-16-8)
- 6-(Trifluoromethyl)nicotinic Acid Hydrazide (CAS 386715-32-8)
- 6-(Trifluoromethyl)picolinohydrazide (CAS 883037-22-7)
- 6-Methyl-4-(trifluoromethyl)-2,6-dihydropyrazolo[3,4-c]pyrazol-3-amine (CAS 478047-15-3)
- N'-(Trifluoromethyl)nicotinohydrazide (CAS 923288-65-7)
- 2-(4-(Trifluoromethyl)pyridin-2-yl)acetic acid (CAS 1000515-78-5)
Recommended Standards
- 3-Methylphenylethyl bromide (CAS 16799-08-9)
- N-Hydroxy-4-(trifluoromethyl)-3-pyridinecarboximidamide (CAS 175204-85-0)
- (1-Bromopropyl)cyclohexane (CAS 1528959-45-6)
- N-Hydroxy-5-(trifluoromethyl)picolinimidamide (CAS 175277-44-8)
- (R)-2-Amino-4-(4-chlorophenyl)butanoic acid (CAS 157684-00-9)
- 6-Iodoquinoline-8-carboxylic acid (CAS 70585-50-1)
- 1-(7-Fluorobenzofuran-2-yl)-2-methylpropan-1-one (CAS 1478017-69-4)
- Methyl 1-(2-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011397-81-1)
- (3S,4S)-1-(tert-butoxycarbonyl)-4-(4-methoxyphenyl)-3-methylpyrrolidine-3-carboxylic acid (CAS 1835266-89-1)
- 6290-05-7 Ethyl N-(2-ethoxy-2-oxoethyl)glycinate Glycine, N-(2-ethoxy-2-oxoethyl)-, ethyl ester Acetic acid, iminodi-, diethyl ester N,N-Bis(ethoxycarbonylmethyl)amine Diethyl iminodiacetate EINECS 228-533-6 Iminodiacetic acid diethyl ester NSC 6950 (CAS 6290-05-7)
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- 1-((2-Bromophenyl)sulfonyl)-3-((furan-2-ylmethyl)sulfonyl)pyrrolidine (CAS 1798537-67-3)
- Axitinib Impurity 83 (CAS CATO-C4X-107183)
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