2,2-Bis(trifluoromethyl)-1,3-dioxolane CAS 1765-26-0
| CAS No. | 1765-26-0 |
| Molecular Formula | C5H4F6O2 |
| Molecular Weight | 210.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,2-Bis(trifluoromethyl)-1,3-dioxolane (CAS 1765-26-0), molecular formula C5H4F6O2 and molecular weight 210.07 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,2-Bis(trifluoromethyl)-1,3-dioxolane (C5H4F6O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,2-Bis(trifluoromethyl)-1,3-dioxolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4F6O2 |
| Molecular Weight | 210.07 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Bis Standards
- 2,2-Bis(trifluoromethyl)propanoic acid (CAS 45048-36-0)
- Ethyl 3-(trifluoromethyl)-1,2,4-oxadiazole-5-carboxylate (CAS 1245643-72-4)
- 2-[5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]acetic acid (CAS 1339865-89-2)
- methyl 2-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]acetate (CAS 1803600-75-0)
- ethyl 5-(trifluoromethyl)-1,2,4-oxadiazole-3-carboxylate (CAS 914773-13-0)
- Ethyl 5-(trifluoromethyl)-1,3,4-oxadiazole-2-carboxylate (CAS 944903-98-4)
- [4-methyl-2-(trifluoromethyl)phenyl]boronic acid (CAS 1021860-94-5)
- [3-methyl-4-(trifluoromethyl)phenyl]boronic acid (CAS 864759-67-1)
Recommended Standards
- 4,4,4-Trifluoro-3-(trifluoromethyl)butanoic Acid (CAS 17327-33-2)
- 7-Bromo-3,4-dihydroisoquinoline (CAS 17680-54-5)
- 4-Bromo-3-ethylbenzonitrile (CAS 170230-29-2)
- 6-bromo-2-methoxypyridin-3-ol (CAS 1823333-27-2)
- 1-(2-(Diethylamino)ethyl)-1h-1,2,4-triazol-3-amine (CAS 1179242-06-8)
- 4-(Azetidin-3-yl)-2-chloropyridine (CAS 1260801-95-3)
- 5-Butyl-1H-pyrazole-3-carboxylic acid (CAS 890624-89-2)
- 2-Methyl-3-nitropyridine-6-acetamide (CAS 1806489-88-2)
- [1,1':2',1'':2'',1'''-Quaterphenyl]-2-yl(4-(Dimethylamino)phenyl)(methyl)phosphineoxide (CAS 105521-34-4)
- H-Ala-Ala-Phe-pNA TFA salt (CAS 61043-41-2(Free Base))
- Methyl 1-amino-2,3-dihydro-1h-indene-1-carboxylate (CAS 90104-36-2)
- 2-(aminooxy)-3-methoxypropanoic acid hydrochloride (CAS 2044713-01-9)
- 5,6-Dihydro-4H-thieno[3,4-c]pyrrole (CAS 185065-69-4)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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