5-Bromo-2-chloro-1,3-difluorobenzene CAS 176673-72-6
| CAS No. | 176673-72-6 |
| Molecular Formula | C6H2BrClF2 |
| Molecular Weight | 227.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 227.43 g/mol gives 5-Bromo-2-chloro-1,3-difluorobenzene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Bromo-2-chloro-1,3-difluorobenzene (CAS 176673-72-6), molecular formula C6H2BrClF2 and molecular weight 227.43 g/mol, is a CATO reference standard with documented purity and traceability.
5-Bromo-2-chloro-1,3-difluorobenzene (C6H2BrClF2) contains fluorine/chlorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H2BrClF2 |
| Molecular Weight | 227.43 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- 1-Bromo-4-chloro-2,3-difluorobenzene (CAS 1000574-47-9)
- 2-Bromo-1-chloro-3,5-difluorobenzene (CAS 1020198-58-6)
- 5-Bromo-1-chloro-2,3-difluorobenzene (CAS 1060813-07-1)
- 1-Bromo-5-chloro-2,3-difluorobenzene (CAS 1160573-26-1)
- 1-Bromo-3-chloro-2,5-difluorobenzene (CAS 1160573-67-0)
- 1-Bromo-2-chloro-3,4-difluorobenzene (CAS 1160574-70-8)
- 2-Bromo-1-chloro-3,4-difluorobenzene (CAS 1208077-25-1)
- 2-Bromo-3-chloro-1,4-difluorobenzene (CAS 1208077-34-2)
Recommended Standards
- 1-Bromo-4-chloro-2,5-difluorobenzene (CAS 172921-33-4)
- Pentadecan-8-amine (CAS 18618-64-9)
- 1-Bromo-2-chloro-3,5-difluorobenzene (CAS 187929-82-4)
- 1-Aminopentadecane (CAS 2570-26-5)
- 1-(Trimethylsilyl)-3-fluoro-4-methylbenzene (CAS 845823-16-7)
- 2-(2-(5-Bromo-1H-indol-3-yl)-2-oxoacetamido)-3-phenylpropanoic acid (CAS 97500-76-0)
- 5-Ethyl-8-tosyl-2-oxa-5,8-diazaspiro[3.4]Octane (CAS 1556097-47-2)
- (3R,5S)-Fluvastatin-3,5-acetonide tert-Butyl Ester (CAS 500731-91-9)
- 4-Chloro-2-(ethylthio)-6-methylpyrimidine (CAS 22727-18-0)
- 5-(2-methylpropyl)thiophene-2-carbaldehyde (CAS 104804-16-2)
- Methyl 5-(2-furyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylate (CAS 1142211-08-2)
- 5’-bromo-1’,2’-dihydrospiro[cyclobutane-1,3’-indole] hydrochloride (CAS 1803590-79-5)
- 2-(Naphthalen-1-yl)-4-phenylpyridine (CAS 910795-03-8)
- Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (CAS 122071-54-9)
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