4,5-Bis-trifluoromethyl-pyridin-2-ylamine CAS 176762-33-7
| CAS No. | 176762-33-7 |
| Molecular Formula | C7H4F6N2 |
| Molecular Weight | 230.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,5-Bis-trifluoromethyl-pyridin-2-ylamine (CAS 176762-33-7), molecular formula C7H4F6N2 and molecular weight 230.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,5-Bis-trifluoromethyl-pyridin-2-ylamine (C7H4F6N2) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F6N2 |
| Molecular Weight | 230.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
- 4,6-Bis(trifluoromethyl)pyridin-2-amine (CAS 112110-08-4)
- 3,5-Bis(trifluoromethyl)pyridin-2-amine (CAS 116593-01-2)
- 5,6-Bis(trifluoromethyl)pyridin-2-amine (CAS 1246466-56-7)
- 2,5-Bis(trifluoromethyl)pyridin-3-amine (CAS 1803804-90-1)
- 2,4-Bis(trifluoromethyl)phenol (CAS 908848-70-4)
- 2,5-Bis(trifluoromethyl)phenol (CAS 779-88-4)
- 2,6-Bis(trifluoromethyl)phenol (CAS 46377-35-9)
- 2,6-Bis(trifluoromethyl)pyridin-4-amine (CAS 78448-45-0)
Recommended Standards
- 4,4,5,5-Tetramethyl-2-(1-phenylvinyl)-1,3,2-dioxaborolane (CAS 143825-84-7)
- 4-Difluoromethoxy-3-fluorobenzotrifluoride (CAS 1803778-22-4)
- 2,4,5-Trifluoro-3-methoxybenzotrifluoride (CAS 1429056-27-8)
- 1-(Difluoromethoxy)-2-fluoro-3-(trifluoromethyl)benzene (CAS 1417569-57-3)
- 6-Amino-3-methoxy-2-methylphenol (CAS 776239-08-8)
- 2-[(2R)-piperazin-2-yl]acetonitrile;hydrochloride (CAS 2306253-88-1)
- 1,4,6-Tribromodibenzo[b,d]furan (CAS 617707-43-4)
- 1-Isothiocyanato-8-(methylsulfenyl)-octane (CAS 4430-41-5)
- Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (CAS 40971-35-5)
- 5-(1-Ethylpiperidin-2-yl)pyridin-2-amine (CAS 1352482-50-8)
- 3-(2,4-Dichlorophenyl)-5-methyl-1,6-diazatricyclo[6.2.2.0^{2,7}]dodeca-2(7),4-diene-4-carbonitrile (CAS 866134-70-5)
- (3-Bromothiophen-2-yl)(2-chlorophenyl)methanone (CAS 887573-01-5)
- Ethyl 4-(5-methylpyridin-2-yl)-3-oxobutanoate (CAS 1855859-35-6)
- [His]1-Acetylated Semaglutide (CAS CATO-C4X-2226219)
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