3-[1-(3-Fluoro-4-methylbenzoyl)piperidin-4-yl]-4-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1775311-27-7
| CAS No. | 1775311-27-7 |
| Molecular Formula | C22H22F2N4O2 |
| Molecular Weight | 412.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-[1-(3-Fluoro-4-methylbenzoyl)piperidin-4-yl]-4-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775311-27-7) is a high-purity analytical reference standard with the molecular formula C22H22F2N4O2 and a molecular weight of 412.43 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 3-[1-(3-Fluoro-4-methylbenzoyl)piperidin-4-yl]-4-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 412.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 3-[1-(3-Fluoro-4-methylbenzoyl)piperidin-4-yl]-4-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22F2N4O2 |
| Molecular Weight | 412.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- Uvarigranol C (CAS 172104-04-0)
- 3-[1-(2,6-Difluorobenzoyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775397-13-1)
- DMP 543 (CAS 160588-45-4)
- (2R,3S)-5-acetoxy-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate (CAS 40491-01-8)
- 1-(4-Aminophenyl)-N-(2-methoxyethyl)-1h-pyrazole-3-carboxamide (CAS 1155164-49-0)
- 6-Fluoro-8-(trifluoromethyl)quinoline (CAS 1065074-24-9)
- Bromo-PEG5-Boc (CAS 1415800-38-2)
- 3-[2-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-oxoethyl]-1,3-benzoxazol-2(3H)-one (CAS 903185-31-9)
- 7-Chloro-2,1,3-benzoxadiazole-4-sulfonamide (CAS 346593-12-2)
- 4-Bromo-2-(piperidin-4-yl)pyridine (CAS 1260848-37-0)
- 3-(4-Chlorophenyl)-4-oxo-N-phenyl-3,4-dihydrophthalazine-1-carboxamide (CAS 86671-80-9)
- 3-(2-BRomoethoxy)phenol (CAS 107332-83-2)
- 4-[(4-bromo-1H-pyrazol-1-yl)methyl]-5-methylfuran-2-carboxylic acid (CAS 1248793-48-7)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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