3-{1-[2-(3-chloro-4-methoxyphenyl)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1775357-95-3
| CAS No. | 1775357-95-3 |
| Molecular Formula | C23H25ClN4O3 |
| Molecular Weight | 440.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 440.92 g/mol gives 3-{1-[2-(3-chloro-4-methoxyphenyl)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-{1-[2-(3-chloro-4-methoxyphenyl)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775357-95-3), molecular formula C23H25ClN4O3 and molecular weight 440.92 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 3-{1-[2-(3-chloro-4-methoxyphenyl)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 440.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-{1-[2-(3-chloro-4-methoxyphenyl)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN4O3 |
| Molecular Weight | 440.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related chloro Standards
- 3-{1-[2-(4-chloro-2-methylphenoxy)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775547-10-8)
- N-(3-Chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine (CAS 305866-70-0)
- 2-((2-Chloro-6-fluorobenzyl)thio)-1-(3-methoxyphenyl)-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole 5,5-dioxide (CAS 921158-60-3)
- 4-Chloro-N-[(4-ethyl-5-{[(4-fluorophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)methyl]benzene-1-sulfonamide (CAS 338421-94-6)
- 4-[2-[5-Chloro-1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]hydrazinyl]benzenesulfonamide (CAS 2380245-48-5)
- N-(5-Chloro-3-(phenylsulfonyl)-1H-indol-2-yl)-2-phenoxyacetamide (CAS 918493-89-7)
- 4-[4-[5-(5-Chloro-6-isopropoxy-3-pyridyl)-1,2,4-oxadiazol-3-yl]-1-indolyl]butanoic Acid (CAS 1034688-30-6)
- 4-(4-((3-(5-Chloro-2-methoxyphenyl)ureido)methyl)phenoxy)-N-methylpicolinamide (CAS 1349244-89-8)
Recommended Standards
- 7-(2-Chlorophenyl)-2-(4-(2-fluorophenyl)piperazin-1-yl)thieno[3,2-d]pyrimidin-4-ol (CAS 1243104-77-9)
- 7-(3-Chlorophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one (CAS 1243089-53-3)
- 3-{1-[2-(2-chlorophenyl)acetyl]piperidin-4-yl}-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775559-69-7)
- 7-(2-Chlorophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one (CAS 1243085-32-6)
- 3-(4-Nitro-1,3-dioxoisoindolin-2-yl)benzoic acid (CAS 300405-52-1)
- 6-(4-Methoxyphenyl)-5-(piperazin-1-yl)pyridazin-3(2H)-one (CAS 220967-37-3)
- 6-chloro-N-cyclopentylpyridine-3-sulfonamide (CAS 923230-05-1)
- 4-Ethyl-n'-hydroxybenzene-1-carboximidamide (CAS 65264-05-3)
- 5-(3-Hydroxy-3-methylbut-1-yn-1-yl)furan-2-carboxylic acid (CAS 1177362-04-7)
- (2R,6R)-2-Methyl-6-undecylpiperidine (CAS 137038-57-4)
- 3,5-Difluoro-4-(difluoromethyl)pyridine (CAS 1804935-03-2)
- 1-(6-Ethoxypyrimidin-4-yl)piperidin-4-ol (CAS 1065484-28-7)
- 1,4-Dimethyl-3-(pentan-2-yl)-1h-pyrazol-5-amine (CAS 1152651-69-8)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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