4-[(4-Fluorophenyl)methyl]-3-[1-(3-methoxybenzoyl)piperidin-4-yl]-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1775379-13-9
| CAS No. | 1775379-13-9 |
| Molecular Formula | C22H23FN4O3 |
| Molecular Weight | 410.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-[(4-Fluorophenyl)methyl]-3-[1-(3-methoxybenzoyl)piperidin-4-yl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775379-13-9), a certified reference material (molecular formula C22H23FN4O3, MW 410.44 g/mol) for analytical method development and quality control.
4-[(4-Fluorophenyl)methyl]-3-[1-(3-methoxybenzoyl)piperidin-4-yl]-4,5-dihydro-1H-1,2,4-triazol-5-one (C22H23FN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H23FN4O3 |
| Molecular Weight | 410.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Fluorophenyl Standards
- 4-[(4-Fluorophenyl)methyl]-3-[1-(2-phenoxyacetyl)piperidin-4-yl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775541-85-9)
- 3-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)-5-methyl-5-phenylimidazolidine-2,4-dione (CAS 956263-04-0)
- 6-(4-Fluorophenyl)-7-(p-tolyl)-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine (CAS 303094-24-8)
- 3-((3-((N-(4-Fluorophenyl)-4-methylphenyl)sulfonamido)-2-hydroxypropyl)amino)propanoic acid (CAS 1021222-24-1)
- 1-(4-Fluorophenyl)-N-((1-(2-phenoxyacetyl)piperidin-4-yl)methyl)cyclopropane-1-carboxamide (CAS 1286733-12-7)
- 5-(((6-(4-Fluorophenyl)pyridazin-3-yl)thio)methyl)-3-(4-(methylthio)phenyl)-1,2,4-oxadiazole (CAS 1114915-23-9)
- 5-(((6-(2-Fluorophenyl)pyridazin-3-yl)thio)methyl)-3-(4-(methylthio)phenyl)-1,2,4-oxadiazole (CAS 1115285-99-8)
- 6-(4-Fluorophenyl)-4-phenyl-3-(4-phenylpiperazin-1-yl)pyridazine (CAS 190776-50-2)
Recommended Standards
- 3-[1-(4-Fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775337-52-4)
- 3-[1-(2-Fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775507-37-3)
- 3-{1-[2-(4-fluorophenoxy)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775313-81-9)
- 3-[1-(3-Fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775526-12-9)
- Croscarmellose Sodium (CAS 74811-65-7)
- 3-(4-Fluorophenyl)-1H-pyrazol-5-amine (CAS 1242422-48-5)
- 3-(5-Fluoro-2-nitrophenyl)-1-methyl-1h-pyrazol-5-amine (CAS 1179718-08-1)
- 4-(1,3-Dimethyl-1h-1,2,4-triazol-5-yl)-2-methylaniline (CAS 1247125-25-2)
- (R)-1-Fluoro-1,1-diphenylpropan-2-amine (CAS 352534-91-9)
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- 4-(Azetidin-3-yl)-2,2-dimethylmorpholine bis(2,2,2-trifluoroacetate) (CAS 1523606-35-0)
- Liraglutide (CAS 204656-20-2)
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