N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide CAS 1775409-06-7
| CAS No. | 1775409-06-7 |
| Molecular Formula | C21H22BrN3O2 |
| Molecular Weight | 428.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide.
N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775409-06-7), molecular formula C21H22BrN3O2 and molecular weight 428.32 g/mol, is a CATO reference standard with documented purity and traceability.
N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (C21H22BrN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22BrN3O2 |
| Molecular Weight | 428.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related N Standards
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- N-(2-(2-Bromophenyl)benzo[d]oxazol-5-yl)-5-nitrofuran-2-carboxamide (CAS 329198-70-1)
- 5-((4-Bromophenyl)thio)-4-chloro-2-(3-chlorophenyl)pyridazin-3(2H)-one (CAS 320421-80-5)
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Recommended Standards
- N-(4-Bromo-3-methylphenyl)-5-methyl-11-oxo-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574622-16-4)
- 3-(4-Benzylpiperazin-1-yl)-1-(4-bromophenyl)pyrrolidine-2,5-dione (CAS 299408-53-0)
- (2S,4S)-4-(2-Bromo-4-isopropylphenoxy)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid (CAS 1354485-57-6)
- 4-(1-Nitronaphthalen-2-yl)-1-(3-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 321998-74-7)
- 2-Bromo-4-(tert-butyl)thiazole-5-carboxylic acid (CAS 81569-33-7)
- Ethyl Phenyl Sulfide (CAS 622-38-8)
- 3-Cyano-N-(4-methoxybenzyl)benzenesulfonamide (CAS 1018240-62-4)
- 2,2,2-trifluoroethyl 5-bromopyridin-2-ylcarbamate (CAS 1087788-73-5)
- (1R,5R)-3,3,5-Trimethylcyclohexanamine (CAS 1821723-32-3)
- Fudosteine Impurity 16 HCl (CAS CATO-C4X-144716)
- 4-bromo-2,2-dimethylbutanenitrile (CAS 1240955-62-7)
- Calcipotriol EP Impurity G (CAS CATO-C4X-12227)
- Methyl 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylate (CAS 102437-87-6)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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