4-{4-[4-(4-methylphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]piperidine-1-carbonyl}benzonitrile CAS 1775449-61-0
| CAS No. | 1775449-61-0 |
| Molecular Formula | C22H21N5O2 |
| Molecular Weight | 387.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-{4-[4-(4-methylphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]piperidine-1-carbonyl}benzonitrile (C22H21N5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-{4-[4-(4-methylphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]piperidine-1-carbonyl}benzonitrile (CAS 1775449-61-0), molecular formula C22H21N5O2 and molecular weight 387.43 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-{4-[4-(4-methylphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]piperidine-1-carbonyl}benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21N5O2 |
| Molecular Weight | 387.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 5 |
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Recommended Standards
- N-Cyclopentyl-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775386-86-1)
- N-Cyclohexyl-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775507-93-1)
- Methyl (Z)-3-(Biphenyl-4-yl)-2-(Cbz-amino)acrylate (CAS 176794-74-4)
- 6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine (CAS 179248-61-4)
- (E)-[1-(Pyridin-2-yl)ethylidene]amino 4-methylbenzene-1-sulfonate (CAS 74209-50-0)
- 3-Chloro-3-phenylacrylonitrile (CAS 78583-84-3)
- 8-Acetyl-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (CAS 57369-01-4)
- Bis(3-chloro-2,2,3,3-tetrafluoropropyl) sulphate (CAS 232602-74-3)
- 2-Bromo-1-isopropyl-4-nitrobenzene (CAS 101980-41-0)
- 4,8-Bis[5-(2-ethylhexyl)thiophen-2-yl]benzo[1,2-b:4,5-b']dithiophene (CAS 1352642-35-3)
- Bis((3,5-dimethylisoxazol-4-yl)methyl)amine (CAS 1258764-91-8)
- 5-Ethyl-1-(3-(trifluoromethyl)benzyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1338658-52-8)
- 1-Allyl-4-butoxybenzene (CAS 1256467-99-8)
- Neuropeptide Y (22-36) (CAS 119019-65-7)
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