N-[(4-Chlorophenyl)methyl]-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide CAS 1775487-64-3
| CAS No. | 1775487-64-3 |
| Molecular Formula | C21H22ClN5O4 |
| Molecular Weight | 443.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-[(4-Chlorophenyl)methyl]-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide.
N-[(4-Chlorophenyl)methyl]-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775487-64-3) is a high-purity analytical reference standard with the molecular formula C21H22ClN5O4 and a molecular weight of 443.88 g/mol.
N-[(4-Chlorophenyl)methyl]-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (C21H22ClN5O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H22ClN5O4 |
| Molecular Weight | 443.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related N Standards
- N-[(2-Chlorophenyl)methyl]-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775308-47-8)
- N-(2-Chlorophenyl)-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]acetamide (CAS 1775337-99-9)
- N-(4-Chlorophenyl)-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]acetamide (CAS 1775403-13-8)
- N-(3-Chlorophenyl)-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]acetamide (CAS 1775427-18-3)
- 4-(4-Chlorophenyl)-3-((2,6-difluorobenzyl)thio)-5-(4-methoxyphenyl)-4H-1,2,4-triazole (CAS 578005-10-4)
- N-(2-(5-(2-Chlorophenyl)-1-(furan-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide (CAS 923193-58-2)
- (E)-{[2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]methylidene}({[3-(trifluoromethyl)phenyl]methoxy})amine (CAS 478257-49-7)
- Ethyl 1-(4-chlorophenyl)-3-methyl-4-{[2-(morpholin-4-yl)ethyl]amino}-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 866132-85-6)
Recommended Standards
- N-(3-Chloro-2-methylphenyl)-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775558-22-9)
- N-(5-Chloro-2-methylphenyl)-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]acetamide (CAS 1775421-73-2)
- ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2,3a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate (CAS 2278357-60-9)
- N-(3-Chloro-2-methylphenyl)-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]acetamide (CAS 1775403-86-5)
- 5-(4-(Hydroxymethyl)phenyl)nicotinonitrile (CAS 1349717-61-8)
- 3-Hydroxy-N-(4-methylpyridin-3-yl)-4-nitrobenzamide (CAS 1797793-89-5)
- 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-carboxylic acid hydrochloride 933689-86-2 FS-6394 (CAS 933689-86-2)
- D-aminoluciferin (CAS 118969-27-0)
- Potassium 4-benzyl-1-(tert-butoxycarbonyl)piperazin-2-yltrifluoroborate (CAS 1684443-08-0)
- 6-(Chloromethyl)-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-amine (CAS 2179277-94-0)
- 1-Methanesulfonyl-4-[4-(trifluoromethoxy)phenoxy]benzene (CAS 286844-91-5)
- Olprinone Impurity 28 (CAS CATO-C4X-204328)
- Tocopherol Impurity 25 (CAS 69371-91-1)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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