4-(4-Methylphenyl)-3-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1775519-41-9
| CAS No. | 1775519-41-9 |
| Molecular Formula | C22H21F3N4O2 |
| Molecular Weight | 430.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Methylphenyl)-3-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one.
4-(4-Methylphenyl)-3-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775519-41-9), molecular formula C22H21F3N4O2 and molecular weight 430.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(4-Methylphenyl)-3-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one (C22H21F3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(4-Methylphenyl)-3-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21F3N4O2 |
| Molecular Weight | 430.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Methylphenyl Standards
- 4-(4-Methylphenyl)-3-{1-[3-(trifluoromethyl)benzoyl]piperidin-4-yl}-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775547-05-1)
- {1-methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methyl N-phenylcarbamate (CAS 318247-44-8)
- N-(4-Methylphenyl)-2-[3-oxo-8-(piperidine-1-sulfonyl)-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-2-yl]acetamide (CAS 1779131-88-2)
- {4-[(4-methylphenyl)sulfanyl]-3-nitrophenyl}methyl N-(4-chlorophenyl)carbamate (CAS 320424-08-6)
- {1-methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methyl 3-methylbenzoate (CAS 318247-63-1)
- 3-(4-Methylphenyl)-5-({[4-(4-methylphenyl)-5-(pyrrolidin-1-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}methyl)-1,2,4-oxadiazole (CAS 920829-44-3)
- 1-(4-Methylphenyl)-4-phenyl-3-({[3-(trifluoromethyl)phenyl]sulfanyl}methyl)azetidin-2-one (CAS 866049-20-9)
- 6-[(4-Ethyl-5-{[(4-methylphenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)methoxy]-2-phenyl-2,3-dihydropyridazin-3-one (CAS 692737-13-6)
Recommended Standards
- 2-[4-(3-Methylpyrazin-2-yl)phenyl]-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide (CAS 1146395-46-1)
- 4-[5-(3-Nitrophenyl)-1H-pyrazol-3-yl]-1-{[4-(trifluoromethyl)phenyl]methyl}piperidine (CAS 1030386-16-3)
- (2-(Diphenylphosphino)-1-hydroxyethyl)diphenylphosphine oxide (CAS 65220-79-3)
- 1-[(4-Nitrophenyl)methyl]-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine (CAS 1030386-08-3)
- Amino-(4-methoxy-naphthalen-1-YL)-acetic acid (CAS 1100358-37-9)
- (12-Hydroxydodecyl)phosphonic acid (CAS 198065-36-0)
- Sulfisozole sodium (CAS 79921-43-0)
- (S)-Pyrrolidin-2-yl butyrate (CAS 221911-70-2)
- 1-Phenyl-N-(thiophen-2-ylmethyl)ethan-1-amine (CAS 680185-68-6)
- Neuromedin N (CAS 92169-45-4)
- 3-(Methylamino)-1-phenylpiperidin-2-one (CAS 1311313-94-6)
- (S)-3-((4-Chlorophenyl)thio)pyrrolidine hydrochloride (CAS 1354018-01-1)
- N-(bicyclo[2.2.1]Heptan-2-ylmethyl)propan-2-amine (CAS 22441-70-9)
- Vialox Peptide(Pentapeptide-3) (CAS 135679-88-8)
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