Polmacoxib Impurity 5 CAS 1778703-66-4
| CAS No. | 1778703-66-4 |
| Molecular Formula | C21H19FO6S |
| Molecular Weight | 418.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Polmacoxib Impurity 5 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 418.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Polmacoxib Impurity 5 (CAS 1778703-66-4), a pharmacopoeial impurity reference standard (molecular formula C21H19FO6S, MW 418.44 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Polmacoxib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19FO6S |
| Molecular Weight | 418.44 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Polmacoxib Standards
Recommended Standards
- Minocycline Impurity 61 (CAS CATO-C4X-169961)
- Gadobutrol Impurity 101 (CAS 835640-27-2)
- Nimodipine Impurity 30 (CAS CATO-C4X-138530)
- Nimodipine (CAS 66085-59-4)
- Foscarnet Sodium EP Impurity C (CAS 72304-94-0)
- Fenofibrate Impurity N1 (CAS 55270-71-8)
- Cenobamate Impurity 21 (CAS CATO-C4X-241621)
- Quinestrol (CAS 152-43-2)
- 4-(2-Cyclohexylethoxy)-2-(trifluoromethyl)aniline (CAS 946662-99-3)
- 2-(Methylamino)acetohydrazide (CAS 37115-47-2)
- 1,2,4,5-Tetrakis(trifluoromethyl)benzene 1,2,4,5-Tetrakis-trifluoromethyl-benzene 320-23-0 (CAS 320-23-0)
- 3-allyl-7-methyl-2-thioxo-2,3,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(1H)-one (CAS 307512-22-7)
- 2-Bromo-3,5-dinitrothiophene (CAS 2160-38-5)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com