Polmacoxib Impurity 4 Sodium Salt CAS 1778703-67-5
| CAS No. | 1778703-67-5 |
| Molecular Formula | C18H14FO4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Polmacoxib Impurity 4 Sodium Salt (CAS 1778703-67-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14FO4SNa and a molecular weight of 368.35 g/mol.
The molecular framework of Polmacoxib Impurity 4 Sodium Salt (C18H14FO4SNa) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Polmacoxib Impurity 4 Sodium Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14FO4S Na |
| Molecular Weight | 368.35 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Polmacoxib Standards
Recommended Standards
- Sarpogrelate Impurity 18 (CAS 1659311-47-3(free base))
- Cisatracurium Besylate EP Impurity O (CAS 2803857-42-1)
- Tinidazole Impurity 17 (CAS CATO-C4X-193017)
- Methyl 4-amino-4-(4-chlorophenyl)butanoate (CAS 1184634-07-8)
- 3-(4-Chlorophenyl)-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 109888-59-7)
- N-methyl-1-(1-phenyl-1H-pyrazol-4-yl)methanamine hydrochloride (CAS 868552-05-0)
- 2-Chloro-5-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridine (CAS 337920-77-1)
- Methyl 3-Chloro-2-fluoro-5-nitrobenzoate (CAS 1509132-39-1)
- 3-hydroxy-5-methylpyridine-2-carboxylic acid hydrobromide (CAS 1461705-76-9)
- Peptide 431 (CAS CATO-CPTD788431)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com