2-fluoro-6-(trifluoromethoxy)benzene-1-sulfonyl chloride CAS 178049-87-1

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-fluoro-6-(trifluoromethoxy)benzene-1-sulfonyl chloride.

2-fluoro-6-(trifluoromethoxy)benzene-1-sulfonyl chloride (CAS 178049-87-1), molecular formula C7H3ClF4O3S and molecular weight 278.61 g/mol, is a CATO reference standard with documented purity and traceability.

2-fluoro-6-(trifluoromethoxy)benzene-1-sulfonyl chloride (C7H3ClF4O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-fluoro-6-(trifluoromethoxy)benzene-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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