Argatroban Impurity 135 CAS 1780572-69-1
| CAS No. | 1780572-69-1 |
| Molecular Formula | C10H8ClNO2S |
| Molecular Weight | 241.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 241.69 g/mol gives Argatroban Impurity 135 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Argatroban Impurity 135 (CAS 1780572-69-1, C10H8ClNO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Argatroban Impurity 135 (C10H8ClNO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Argatroban Impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClNO2S |
| Molecular Weight | 241.69 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Argatroban Standards
- Argatroban Impurity 13 (CAS 94975-84-5)
- Argatroban Impurity 21 (CAS CATO-C4X-100721)
- Argatroban Impurity 29 (CAS 74863-82-4)
- Argatroban Impurity 122 (CAS CATO-C4X-1007122)
- Argatroban Impurity 41 (CAS CATO-C4X-100741)
- Argatroban Impurity 51 (CAS CATO-C4X-100751)
- Argatroban Impurity 88 (CAS CATO-C4X-100788)
- Argatroban Impurity 87 (CAS CATO-C4X-100787)
Recommended Standards
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- methyl 5-chlorosulfonylpyridine-3-carboxylate (CAS 594839-14-2)
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