2-(3,6-Dihydro-2H-pyran-4-yl)-2,2-difluoroacetic acid CAS 1780960-02-2
| CAS No. | 1780960-02-2 |
| Molecular Formula | C7H8F2O3 |
| Molecular Weight | 178.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(3,6-Dihydro-2H-pyran-4-yl)-2,2-difluoroacetic acid (C7H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(3,6-Dihydro-2H-pyran-4-yl)-2,2-difluoroacetic acid (CAS 1780960-02-2), a certified reference material (molecular formula C7H8F2O3, MW 178.13 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8F2O3 |
| Molecular Weight | 178.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
Related Dihydro Standards
- 2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid (CAS 1190310-95-2)
- 2-Oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid (CAS 1190313-18-8)
- 4-Oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid (CAS 1190314-55-6)
- 2-Oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid (CAS 1190317-48-6)
- 2-Oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylic acid (CAS 1190318-74-1)
- 2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid (CAS 1190318-92-3)
- 2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid (CAS 1190319-78-8)
- 5-Oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (CAS 1190321-95-9)
Recommended Standards
- 2,2-Difluoro-2-(3-oxocyclopentyl)acetic acid (CAS 1780193-51-2)
- 2,5-Difluoro-4-methylbenzodifluoride (CAS 1803735-01-4)
- 2-Fluoro-4-methyl-1-(trifluoromethyl)benzene (CAS 158364-83-1)
- 2,6-Difluoro-3-methylbenzodifluoride (CAS 1803792-93-9)
- 6-Bromo-7-chloroquinazolin-2(1H)-one (CAS 1036757-12-6)
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