3-(Difluoromethyl)-4-fluorobenzoic acid CAS 1781570-25-9
| CAS No. | 1781570-25-9 |
| Molecular Formula | C8H5F3O2 |
| Molecular Weight | 190.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(Difluoromethyl)-4-fluorobenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-(Difluoromethyl)-4-fluorobenzoic acid (CAS 1781570-25-9), molecular formula C8H5F3O2 and molecular weight 190.12 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(Difluoromethyl)-4-fluorobenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O2 |
| Molecular Weight | 190.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 4-(difluoromethyl)-2-fluorobenzoic acid (CAS 1270981-57-1)
- 1429421-95-3 5-(difluoromethyl)-2-fluorobenzoic acid Z2630881496 (CAS 1429421-95-3)
- 4-(Difluoromethyl)-3-fluorobenzoic acid (CAS 1780188-78-4)
- 3-(Difluoromethyl)-2-fluorobenzoic acid (CAS 1780810-87-8)
- 2-(Difluoromethyl)-5-fluorobenzoic acid (CAS 2248349-16-6)
- 3-(Difluoromethyl)-5-fluorobenzoic acid (CAS 2248405-07-2)
- Methyl 2-(2-(difluoromethyl)furan-3-yl)acetate (CAS 1706464-72-3)
- 6-(Difluoromethyl)-4-oxo-4H-pyran-2-carboxylic acid (CAS 1083402-18-9)
Recommended Standards
- 2,3,4-Trifluoro-6-methoxybenzaldehyde (CAS 1785350-84-6)
- 2-Amino-6-(difluoromethyl)-3-fluoroisonicotinaldehyde (CAS 1803673-32-6)
- 2,4,6-Trifluoro-3-methylbenzoic acid (CAS 1706435-01-9)
- 2-Amino-5-(difluoromethyl)-3-fluoroisonicotinaldehyde (CAS 1804485-82-2)
- 4-(Trifluoromethyl)-2h,3h,5h,6h,7h-cyclopenta[c]pyridazin-3-one (CAS 929975-31-5)
- 2-[5-amino-3-(4-bromophenyl)-1h-pyrazol-1-yl]ethan-1-ol (CAS 1152967-07-1)
- 2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 438596-96-4)
- 2,3,4,5-Tetrafluoro-6-methoxybenzoic acid (CAS 38512-77-5)
- 2-Bromo-1-(5-phenylthiophen-2-yl)ethan-1-one (CAS 10531-43-8)
- Methyl 2-iodo-6-nitrobenzoate (CAS 5471-78-3)
- 2-Amino-1-(trifluoromethyl)cyclobutan-1-ol hydrochloride (CAS 2387600-19-1)
- 1-(4-Chlorophenyl)-4-oxopyrrolidine-3-carbonitrile (CAS 23935-48-0)
- 6-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile (CAS 1449278-80-1)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
Why CATO?
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