2-(Methylsulfonyl)-5-(trifluoromethyl)pyridine CAS 178204-50-7
| CAS No. | 178204-50-7 |
| Molecular Formula | C7H6F3NO2S |
| Molecular Weight | 225.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 225.19 g/mol gives 2-(Methylsulfonyl)-5-(trifluoromethyl)pyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-(Methylsulfonyl)-5-(trifluoromethyl)pyridine (CAS 178204-50-7), a certified reference material (molecular formula C7H6F3NO2S, MW 225.19 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Methylsulfonyl)-5-(trifluoromethyl)pyridine (C7H6F3NO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(Methylsulfonyl)-5-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO2S |
| Molecular Weight | 225.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methylsulfonyl Standards
- 2-(Methylsulfonyl)-3-(trifluoromethyl)pyridine (CAS 886498-06-2)
- 1-(Methylsulfonyl)indoline-2,3-dione (CAS 58837-08-4)
- 2-(Methylsulfonyl)pyrido[2,3-d]pyrimidin-7(1H)-one (CAS 211244-92-7)
- 4-Methylsulfonyl-2-nitrofluorobenzene 2-fluoro-5-methylsulphonyl nitrobenzene 1-fluoro-4-methanesulfonyl-2-nitro-benzene 2-fluoro-5-methylsulfonylnitrobenzene 1-fluoro-4-methylsulfonyl-2-nitrobenzene 2-fluoro-5-methyl sulfonyl nitrobenzene 1-fluoro-4-(methylsulfonyl)-2-nitrobenzene 2-fluoro-5-methylsulphonylnitrobenzene 1-fluoro-4-(methylsulphonyl)-2-nitrobenzene (3-Nitro-4-fluorophenyl)methyl sulfone 1-Fluoro-4-methanesulfonyl-2-nitrobenzene 4-Fluoro-3-nitrophenyl methyl sulfone 453-72-5 (CAS 453-72-5)
- 1-(Methylsulfonyl)-2,3-dihydroquinolin-4(1H)-one (CAS 22366-61-6)
- N-(4-(methylsulfonyl)phenyl)acrylamide (CAS 852146-99-7)
- 2-(3-(Methylsulfonyl)phenyl)pyrrolidine (CAS 1016521-37-1)
- 2-(4-(Methylsulfonyl)phenyl)pyrrolidine (CAS 1016751-26-0)
Recommended Standards
- 2-Trifluoromethanesulfonylaniline (CAS 17095-18-0)
- 2-(Difluoromethoxy)-5-propionylbenzonitrile (CAS 1803866-97-8)
- Ethyl 5,6-Difluoro-1H-indole-2-carboxylate (CAS 169674-34-4)
- 2-(2-Cyano-4-(difluoromethyl)-5-methylphenyl)acetic acid (CAS 1804848-92-7)
- 2,2,2-Trichloroethyl Chloroformate (CAS 17341-93-4)
- n-Benzyl-2-(3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamide (CAS 36932-43-1)
- Fmoc-(3S)-1,2,3,4-tetrahydroisoquinoline-3-acetic acid (CAS 270062-99-2)
- 2-((3,5-Dimethylisoxazol-4-yl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 1007952-40-0)
- 4-Methoxy-3-{[(4-methylphenyl)sulfanyl]methyl}benzaldehyde (CAS 438531-19-2)
- 1-Amino-2-methyl-1-(pyridin-2-yl)propan-2-ol (CAS 179123-33-2)
- N-(4-chloro-2-methylphenyl)benzamide (CAS 61495-07-6)
- (S)-1-(2-((Isopropylamino)methyl)pyrrolidin-1-yl)ethanone (CAS 1354020-85-1)
- Tert-butyl (R)-2-(bromomethyl)-4,4-difluoropyrrolidine-1-carboxylate (CAS 2092723-85-6)
- Angiotensin III Antipeptide (CAS 133605-55-7)
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