2-Chloro-5-cyclopropylthiazole-4-carboxylic acid CAS 1783543-40-7
| CAS No. | 1783543-40-7 |
| Molecular Formula | C7H6ClNO2S |
| Molecular Weight | 203.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-5-cyclopropylthiazole-4-carboxylic acid is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-5-cyclopropylthiazole-4-carboxylic acid (CAS 1783543-40-7), molecular formula C7H6ClNO2S and molecular weight 203.65 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-5-cyclopropylthiazole-4-carboxylic acid (C7H6ClNO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-5-cyclopropylthiazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO2S |
| Molecular Weight | 203.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-chloro-1,3-dihydro-2$l^{6},1-benzothiazole-2,2-dione (CAS 111248-90-9)
- 6-chloro-1,3-dihydro-2$l^{6},1-benzothiazole-2,2-dione (CAS 111248-91-0)
- 5-chloro-1,3-dihydro-2$l^{6},1-benzothiazole-2,2-dione (CAS 111310-59-9)
- 5-chloro-6-(methylthio)nicotinic acid (CAS 1184743-95-0)
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- 4-Chloro-2-cyclopropylthiazole-5-carboxylic acid (CAS 1934452-09-1)
Recommended Standards
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