Sildenafil Impurity 246 CAS 1786437-29-3
| CAS No. | 1786437-29-3 |
| Molecular Formula | C23H30N6O2S |
| Molecular Weight | 454.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sildenafil Impurity 246.
As a process- or degradation-related impurity, Sildenafil Impurity 246 (CAS 1786437-29-3, C23H30N6O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sildenafil Impurity 246 (C23H30N6O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 454.59 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sildenafil Impurity 246 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H30N6O2S |
| Molecular Weight | 454.59 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Sildenafil Standards
- Sildenafil Impurity 245 (CAS CATO-C4X-1128245)
- Sildenafil Impurity 285 (CAS CATO-C4X-1128285)
- Sildenafil Impurity 291 (CAS CATO-C4X-1128291)
- Sildenafil EP Impurity F (CAS 139755-82-1)
- Sildenafil Impurity 51 (CAS 263897-18-3)
- Sildenafil Impurity 30 (CAS 139755-95-6)
- Sildenafil Impurity 303 (CAS CATO-C4X-1128303)
- Sildenafil Impurity 270 (CAS 1229017-26-8)
Recommended Standards
- (R)-Octan-2-yl 4-((4-(hexyloxy)benzoyl)oxy)benzoate (CAS 133676-09-2)
- N-(3-Methyl-1H-pyrazol-5-yl)-2-({3-[3-(4-methylpiperidin-1-yl)propyl]-4-oxo-3,4-dihydroquinazolin-2-yl}sulfanyl)acetamide (CAS 896700-78-0)
- (17β)-3,17-Bis[(1-oxopentyl)oxy]-estra-1,3,5(10)-trien-6-one (CAS 1350468-78-8)
- (S)-3-Hydroxy-2-methoxy-5-((2-(trimethylsilyl)ethoxy)methyl)-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinoline-6,14(5H,6aH)-dione (CAS 1964489-90-4)
- Dipivefrine EP Impurity A (CAS 329-65-7)
- Glycyrrhizic Acid Impurity 35 (CAS CATO-C4X-253735)
- Clopidogrel Impurity 6 (CAS 1357474-92-0)
- (Z)-N-(2-Chloroacetoxy)nicotinimidamide (CAS 1401223-72-0)
- 3-Amino-3-methyl-cyclobutanone (CAS 1889643-97-3)
- Ethyl 6-Boc-6-Azaspiro[2.5]octane-1-carboxylate (CAS 1242268-17-2)
- 2-(4-(Difluoromethyl)-3-(trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1804692-94-1)
- 25I-Nb34md (CAS 1391497-81-6)
- 5-(3,4-Dimethoxyphenyl)pyrazine-2,3-dicarbonitrile (CAS 67170-61-0)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com