Atrasentan Impurity 39 CAS 178738-91-5
| CAS No. | 178738-91-5 |
| Molecular Formula | C30H40N2O6 |
| Molecular Weight | 524.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atrasentan Impurity 39 (CAS 178738-91-5, C30H40N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atrasentan Impurity 39 (C30H40N2O6) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H40N2O6 |
| Molecular Weight | 524.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 122 (CAS 173864-35-2)
- Atrasentan Impurity 146 (CAS 1058350-25-6)
- Atrasentan Impurity 150 (CAS 1058402-39-3)
- Atrasentan Impurity 156 (CAS 1059040-11-7)
- Atrasentan Impurity 20 (CAS 1058350-30-3)
- Atrasentan Impurity 38 (CAS 178607-92-6)
- Atrasentan Impurity 40 (CAS 178738-92-6)
- Atrasentan Impurity 41 (CAS 178738-93-7)
Recommended Standards
- di-tert-Butyl 4,4'-((2-(methylthio)pyrimidine-4,6-diyl)bis(oxy))bis(piperidine-1-carboxylate) (CAS 1261231-38-2)
- (R,R)-BaryPhos (CAS 2416226-97-4)
- (S)-tert-butyl 4-(4-(2-(4-((3-fluorophenyl)amino)piperidin-1-yl)-2-oxoethyl)benzyl)-2-methylpiperazine-1-carboxylate (CAS 923565-74-6)
- (S,S)-BaryPhos (CAS 2416226-68-9)
- Methylnaltrexone Bromide Impurity 11 (CAS CATO-C4X-152111)
- Butalbital Impurity 9 (CAS CATO-C4X-19839)
- Indacaterol Impurity 91 (CAS CATO-C4X-150091)
- Methyl 2-(ethylamino)-2-methylpropanoate (CAS 1157699-72-3)
- (E)-N'-(5-(2,4-dichlorobenzoyl)thiazol-2-yl)-N,N-dimethylformimidamide (CAS 865659-42-3)
- (S)-2-Amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)propanamide (CAS 1353996-66-3)
- 1-(4,5-Dimethyl-1,3-dithiol-2-ylidene)piperidinium hexafluorophosphate (CAS 122301-26-2)
- Cholesterol Impurity 17 (CAS 14214-69-8)
- 1-(3-Methoxy-2-propoxyphenyl)-N-methylmethanamine (CAS 709649-53-6)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
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