Cholesterol Impurity 17 CAS 14214-69-8
| CAS No. | 14214-69-8 |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cholesterol Impurity 17 is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Cholesterol Impurity 17 (CAS 14214-69-8, C27H44O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cholesterol Impurity 17 (C27H44O) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cholesterol Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Cholesterol Standards
- Cholesterol EP Impurity C (CAS 651-54-7)
- Cholesterol Impurity 29 (CAS 881024-99-3)
- Cholesterol Impurity 30 (CAS 17608-47-8)
- Cholesterol Impurity 31 (CAS 117556-83-9)
- Cholesterol probe for Smoothened (CAS CATO-C3D-262450)
- Cholesterol Impurity 25 (CAS CATO-C4X-196725)
- Cholesterol Impurity 36 (CAS 7199-91-9)
- Cholesterol EP Impurity A (CAS 80-99-9)
Recommended Standards
- 8-Dehydrocholesterol (CAS 70741-38-7)
- Precalciferol (Previtamin D3) (CAS 1173-13-3)
- Cholecalciferol EP Impurity E (CAS 17592-07-3)
- Cholecalciferol EP Impurity D (CAS 22350-43-2)
- Xanomeline Impurity 18 Fumarate (CAS CATO-C4X-330134)
- Pirfenidone Impurity 9 (CAS CATO-C4X-22299)
- Mirabegron Impurity 57 (CAS 2184223-32-1)
- 1-(1-Phenylcyclopropyl)piperazine hydrochloride (CAS 1346808-46-5)
- Copper, bis(3-aminocrotonophenonato)- (CAS 26748-05-0)
- N-[4-(chloroacetyl)benzyl]-N-methylacetamide (CAS 851903-39-4)
- 1-(1-(3,4-Dichlorophenyl)ethyl)piperazine (CAS 514787-47-4)
- 2-(3-Chloro-1H-pyrazol-1-yl)ethan-1-ol (CAS 1849393-73-2)
- 7-(bromomethyl)-2-methyl-2H-indazole (CAS 1363380-76-0)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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