Ethyl 3-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylate CAS 1787974-00-8
| CAS No. | 1787974-00-8 |
| Molecular Formula | C8H10F3N3O2 |
| Molecular Weight | 237.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 3-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylate (C8H10F3N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Ethyl 3-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylate (CAS 1787974-00-8) is a high-purity analytical reference standard with the molecular formula C8H10F3N3O2 and a molecular weight of 237.18 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10F3N3O2 |
| Molecular Weight | 237.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
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- Methyl 2-amino-3-(3-(trifluoromethyl)-1h-pyrazol-1-yl)propanoate (CAS 1249352-80-4)
- 2-Amino-2-methyl-3-(3-(trifluoromethyl)-1h-pyrazol-1-yl)propanoic acid (CAS 1249846-70-5)
- Ethyl 3-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1328640-51-2)
- 2-Amino-2-methyl-3-(4-(trifluoromethyl)-1h-pyrazol-1-yl)propanoic acid (CAS 1341562-93-3)
- 2-Amino-4-(3-(trifluoromethyl)-1h-pyrazol-1-yl)butanoic acid (CAS 1342672-07-4)
- Ethyl 5-(1-amino-2,2,2-trifluoroethyl)furan-2-carboxylate (CAS 886371-71-7)
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Recommended Standards
- 2,2-difluoro-2H-1,3-benzodioxole-5-sulfonamide (CAS 1710471-90-1)
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- 7-(2,2,2-Trifluoroacetyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid (CAS 1561766-05-9)
- 1-Butyl-5-nitro-3-(trifluoromethyl)-1H-pyrazole (CAS 1881295-58-4)
- 5-Fluoro-2-methylisoindoline-1,3-dione (CAS 63196-44-1)
- 1H-pyrrolo[2,3-b]pyridin-5-amine, 3-(1,1-dimethylethyl)- (CAS 1186501-96-1)
- tert-butyl N-{[1-(1,2,4-oxadiazol-3-ylmethyl)piperidin-3-yl]methyl}carbamate (CAS 1803560-79-3)
- 1-Boc-3,3-difluoropiperidin-4-one Hydrate (CAS 1400264-85-8)
- N-Iodophthalimide (CAS 20919-42-0)
- 2,2,2-trifluoro-1-(pyridin-4-yl)ethan-1-one (CAS 896137-18-1)
- rel-Methyl (1S,3R)-3-((Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylate (CAS 83376-83-4)
- 2,4,4,4-TEtrafluorobut-1-ene (CAS 721946-02-7)
- 3-(3-Chloro-4-fluorophenyl)-N-isopropylacrylamide (CAS 1090341-70-0)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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