3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorobenzaldehyde CAS 179117-82-9
| CAS No. | 179117-82-9 |
| Molecular Formula | C13H18ClFO2Si |
| Molecular Weight | 288.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorobenzaldehyde (CAS 179117-82-9), molecular formula C13H18ClFO2Si and molecular weight 288.82 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorobenzaldehyde (C13H18ClFO2Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H18ClFO2Si |
| Molecular Weight | 288.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F/Cl-containing |
Related tert Standards
- 2-(((Tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine-6-carbonitrile (CAS 1186310-75-7)
- 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chloro-6-methoxypyridine (CAS 944407-72-1)
- (3-(((tert-Butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol-d2 (CAS 2883771-00-2)
- (3-(((tert-Butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol-d2-1 (CAS 2883771-14-8)
- ((Tert-butyldimethylsilyl)imino)(fluoromethyl)(phenyl)-λ6-sulfanone (CAS 825638-25-3)
- 4-(((tert-Butyldimethylsilyl)oxy)methyl)-5-methylthiazole-2-carboxylic acid (CAS 2057426-42-1)
- 4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid (CAS 412343-21-6)
- (6-((tert-Butyldimethylsilyl)oxy)-1H-indol-2-yl)boronic acid (CAS 1203844-24-9)
Recommended Standards
- 2-[[3-(4-chlorophenyl)propyl-methyl-amino]methyl]aniline (CAS 1616351-09-7)
- 3-chloro-1-[3-fluoro-5-methoxy-2-(trimethylsilyl)phenyl]propan-1-one (CAS 1803587-18-9)
- 5-Isopropyl-2-methylbenzo[b]thiophene-3-sulfonyl chloride (CAS 1384428-16-3)
- (2-Chloro-8-methyl-quinolin-3-ylmethyl)-cyclohexyl-amine (CAS 606095-54-9)
- 4,5-Difluoro-2-iodobenzoic Acid (CAS 130137-05-2)
- 4-(4-Bromobenzoyl)-8-methyl-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid (CAS 1326813-64-2)
- 5-Chloro-2-cyclopropylaniline (CAS 104902-30-9)
- 2-(5-Bromo-1H-benzo[d]imidazol-1-yl)ethan-1-amine (CAS 944907-05-5)
- 1,3-dihydrofuro[3,4-c]pyridin-4-amine (CAS 1648750-12-2)
- Methyl 8-oxo-7,8-dihydro[2,7]naphthyridine-4-carboxylate (CAS 1353502-58-5)
- 9-(b-D-Arabinofuranosyl)guanine (CAS 38819-10-2)
- 2-(Difluoromethyl)-6-iodo-4-methylpyridine-3-carboxamide (CAS 1807140-70-0)
- TPBM (CAS 6466-43-9)
- Semaglutide Impurity 160 (x TFA Salt) (CAS CATO-C4X-2226160)
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