1-(2,5-Difluorobenzoyl)piperazine CAS 179334-11-3
| CAS No. | 179334-11-3 |
| Molecular Formula | C11H12F2N2O |
| Molecular Weight | 226.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2,5-Difluorobenzoyl)piperazine (CAS 179334-11-3), molecular formula C11H12F2N2O and molecular weight 226.22 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 1-(2,5-Difluorobenzoyl)piperazine is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 226.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12F2N2O |
| Molecular Weight | 226.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorobenzoyl Standards
- 1-(2,6-Difluorobenzoyl)piperazine (CAS 179334-15-7)
- 1-(2,4-Difluorobenzoyl)piperazine (CAS 926209-09-8)
- 1-(3,4-Difluorobenzoyl)piperazine (CAS 923237-42-7)
- 1-(3,5-Difluorobenzoyl)piperazine (CAS 874942-08-2)
- 4-(2,3-Difluorobenzoyl)piperidine (CAS 1388035-56-0)
- 3-(2,4-Difluorobenzoyl)thiophene (CAS 898771-60-3)
- 3-(3,4-Difluorobenzoyl)-4-methylpyridine (CAS 1187163-84-3)
- 2-(2,6-Difluorobenzoyl)-5-methylpyridine (CAS 1187164-66-4)
Recommended Standards
- 5-(3,3-Difluoropiperidin-1-yl)picolinaldehyde (CAS 1779134-11-0)
- 2-(4,4-Difluoropiperidin-1-yl)nicotinaldehyde (CAS 1779131-73-5)
- Megazol (CAS 19622-55-0)
- 3-(4,4-Difluoropiperidin-1-yl)isonicotinaldehyde (CAS 1779121-73-1)
- 4-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-thiazol-2-amine hydrochloride (CAS 1803592-08-6)
- Daptomycin-d5 (CAS 1356579-56-0)
- 4-[(2,4-Dichlorobenzyl)oxy]piperidinehydrochloride (CAS 1220033-07-7)
- Ethyl 2-benzoyl-3-phenylacrylate (CAS 125105-17-1)
- n-Methyl-1,2,3,4-tetrahydroisoquinoline-7-carboxamide (CAS 949922-29-6)
- 3-ethynylspiro[3.4]octan-3-ol (CAS 2105566-55-8)
- 2-(2,4-Dimethoxybenzoyl)-6-methoxypyridine (CAS 1187168-15-5)
- Ethyl 1-[2-(2-piperidinyl)ethyl]-1H-1,2,3-triazole-4-carboxylate hydrochloride (CAS 1211507-89-9)
- 4-(Azetidin-3-yl)phenol (CAS 4363-15-9)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com