Roflumilast-D4 N-Oxide CAS 1794760-31-8
| CAS No. | 1794760-31-8 |
| Molecular Formula | - |
| Molecular Weight | 423.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roflumilast-D4 N-Oxide.
Roflumilast-D4 N-Oxide (CAS 1794760-31-8) is a high-purity analytical reference standard with the molecular formula C17H10D4Cl2F2N2O4 and a molecular weight of 423.23 g/mol.
Roflumilast-D4 N-Oxide (C17H10D4Cl2F2N2O4) contains deuterium isotope labeling, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Roflumilast-D4 N-Oxide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H10D4Cl2F2N2O4 |
| Molecular Weight | 423.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast N-Oxide (CAS 292135-78-5)
- Roflumilast Impurity 39 (CAS CATO-C4X-108439)
- Roflumilast Impurity 35 (CAS CATO-C4X-108435)
- Roflumilast Impurity 54 (CAS CATO-C4X-108454)
- Roflumilast Impurity 6 (CAS 2368178-29-2)
- Roflumilast Impurity 3 (CAS 1391052-24-6)
- Roflumilast -D4 (CAS 1398065-69-4)
- Roflumilast-d3 (CAS 1189992-00-4)
Recommended Standards
- 3,5-Dibromo-1-tetradecyl-1H-1,2,4-triazole (CAS 1240572-65-9)
- 1-(4-Bromophenyl)-N-{[3-(trifluoromethyl)phenyl]methyl}-1H-pyrrole-2-carboxamide (CAS 477858-93-8)
- 2-Iodo-6-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (CAS 1227268-52-1)
- 2-Deoxy-2-fluoro-α-D-arabinofuranosyl Bromide 3,5-Dibenzoate (CAS 97614-44-3)
- 8-Methoxy-4-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 1566023-26-4)
- 2-(Benzo[d]thiazol-2-ylthio)-1-(4-ethoxyphenyl)ethan-1-one (CAS 313684-16-1)
- 1-(4-Fluorophenyl)-3-phenylprop-2-yn-1-one (CAS 82677-84-7)
- 2-Propenoic acid, homopolymer, compd. with N,N-diethylethanamine (CAS 55576-87-9)
- tert-Butyl 4-hydroxy-4-(mercaptomethyl)piperidine-1-carboxylate (CAS 959701-66-7)
- Potassium (3-fluoro-4-formylphenyl)trifluoroborate (CAS 1451390-71-8)
- Tert-butyl (S)-5-(aminomethyl)-4-azaspiro[2.4]Heptane-4-carboxylate (CAS 2166229-43-0)
- N-Methyl-4-(1-piperazinyl)pyridine-2-carboxamide (CAS 926244-85-1)
- Ethyl 4-oxo-3,4-dihydroquinazoline-7-carboxylate (CAS 1427080-89-4)
- Peptide 442 (CAS CATO-CPTD788442)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com