Quetiapine impurity 71 CAS 1798293-04-5
| CAS No. | 1798293-04-5 |
| Molecular Formula | C13H8ClNOS |
| Molecular Weight | 261.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Quetiapine impurity 71 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Quetiapine impurity 71 (CAS 1798293-04-5, C13H8ClNOS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Quetiapine impurity 71 (C13H8ClNOS) contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H8ClNOS |
| Molecular Weight | 261.73 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine Impurity 89 (CAS CATO-C4X-124489)
- Quetiapine Impurity 47 (CAS 14258-43-6)
- Quetiapine Impurity 52 (CAS CATO-C4X-124452)
- Quetiapine impurity 74 (CAS 99153-65-8)
- Quetiapine Impurity SF (CAS 22871-33-6)
- Quetiapine Impurity 58 (CAS CATO-C4X-124458)
- Quetiapine Impurity 61 (CAS 65141-02-8)
- Quetiapine Impurity 88 (CAS CATO-C4X-124488)
Recommended Standards
- tert-Butyl (2-chloro-4-formylthiophen-3-yl)carbamate (CAS 2732241-91-5)
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- Articaine Impurity 11 (CAS 23964-56-9)
- n-[4-(2-chloroacetyl)phenyl]-n-methylmethanesulfonamide (CAS 851398-37-3)
- Ramelteon Impurity 41 (CAS 196597-16-7)
- Bromfenac Impurity 7 (CAS 61941-56-8)
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- N-(3-allylpyridin-4-yl)pivalamide (CAS 1186311-09-0)
- Ethyl 5-cyclobutyl-1,3,4-oxadiazole-2-carboxylate (CAS 1402233-03-7)
- 1-Methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (CAS 100501-58-4)
- 2-methyl-1H-pyrrolo[2,3-c]pyridine (CAS 65645-56-9)
- 4-[(2-methoxyethoxy)methyl]benzoic acid (CAS 119828-60-3)
- Methyl 5-((4-ethoxyphenyl)carbamoyl)-2-(2-(4-methoxyphenyl)acetamido)-4-methylthiophene-3-carboxylate (CAS 505095-44-3)
- Cholecystokinin Octapeptide free acid (desulfated) (H-2075.0001) (CAS 103974-46-5)
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