Nicotinic Acid EP Impurity B CAS 1802-30-8
| CAS No. | 1802-30-8 |
| Molecular Formula | C12H8N2O4 |
| Molecular Weight | 244.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicotinic Acid EP Impurity B.
Nicotinic Acid EP Impurity B (CAS 1802-30-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8N2O4 and a molecular weight of 244.20 g/mol.
The molecular framework of Nicotinic Acid EP Impurity B (C12H8N2O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicotinic Acid EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8N2O4 |
| Molecular Weight | 244.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Nicotinic Standards
- Nicotinic Acid N-Hydroxysuccinimide Ester (CAS 78348-28-4)
- Nicotinic Acid Riboside (CAS 17720-18-2)
- Nicotinic Acid-13C6,d4 N-Hydroxysuccinimide Ester (CAS 1209457-55-5)
- Nicotinic anhydride (CAS 16837-38-0)
- Nicotinic acid (3-amino-isoindol-1-ylidenE)-hydrazide (CAS 519152-72-8)
- 35812-43-2 Nicotinic acid, 2-(cyclohexylamino)- S 218 5-22-13-00595 (Beilstein Handbook Reference) BRN 0479156 2-(Cyclohexylamino)nicotinic acid (CAS 35812-43-2)
- Nicotinic Acid Benzyl Ester (CAS 94-44-0)
- Nicotinic acid 4-formyl-phenyl ester (CAS 15131-72-3)
Recommended Standards
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- Azacitidine Impurity 27 (CAS 65886-71-7)
- Labetalol Impurity 19 (CAS 76143-20-9)
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- Doxorubicin Dimer Impurity 23 (CAS 201278-93-5)
- Fmoc-Val-Cl (CAS 103321-53-5)
- Opicapone impurity 25 (CAS CATO-C4X-240425)
- tributyl-[(E)-2-tributylstannylvinyl]stannane (CAS 14275-61-7)
- 1-Cyclohexylpiperidin-4-amine dihydrochloride hydrate (CAS 833486-95-6)
- 1-(6-(Isopropylamino)pyridin-3-yl)propan-1-one (CAS 1355177-63-7)
- 4-(4-(Methoxycarbonyl)piperidin-1-yl)-4-oxobutanoic acid (CAS 303994-57-2)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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