4-(Bromomethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-2-sulfonyl chloride CAS 1804370-55-5
| CAS No. | 1804370-55-5 |
| Molecular Formula | C8H4BrClF5NO3S |
| Molecular Weight | 404.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Bromomethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-2-sulfonyl chloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(Bromomethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-2-sulfonyl chloride (CAS 1804370-55-5), molecular formula C8H4BrClF5NO3S and molecular weight 404.54 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, 4-(Bromomethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-2-sulfonyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 404.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrClF5NO3S |
| Molecular Weight | 404.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bromomethyl Standards
- 2-(Bromomethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-6-sulfonyl chloride (CAS 1806773-43-2)
- 3-(3-(Bromomethyl)-5-iodophenyl)-3-(trifluoromethyl)-3H-diazirine (CAS 309250-32-6)
- 1,3,5,5-Tris(bromomethyl)-2,4,6-trimethylbenzene 1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene 21988-87-4 (CAS 21988-87-4)
- 3-(4-(Bromomethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1823183-65-8)
- 4-(Bromomethyl)-1-trityl-1H-imidazole (CAS 562074-49-1)
- 3,3-bis(bromomethyl)-1-(4-methylbenzenesulfonyl)azetidine (CAS 1041026-61-2)
- 3,5-Bis(bromomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 2096469-95-1)
- 2-(3-(Bromomethyl)phenyl)-4,5-diphenylthiazole (CAS 1217863-18-7)
Recommended Standards
- 3-O-Benzyl Estrone Monoethylene Ketal (CAS 162784-26-1)
- (4S,4′S)-2,2′-(1S)-[1,1′-Biphenyl]-2,2′-diylbis[4,5-dihydro-4-(2-methylpropyl)oxazole] (CAS 1428785-62-9)
- Lovastatin Anhydro Acid Sodium Salt (CAS 188067-71-2)
- 3,5-Seco-A-norestran-3-oic Acid 17beta-Hydroxy-5-oxo-benzoate (CAS 122426-44-2)
- 1-(Cyclopropylmethyl)pyrrolidin-3-ol (CAS 331281-31-3)
- (1E,4E)-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one (CAS 53369-00-9)
- 3-Bbenzyloxy)-5-bromo-2-fluorobenzaldehyde (CAS 2624417-13-4)
- 1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-N-methyl-4-piperidinamine dihydrochloride (CAS 1134322-93-2)
- 1-Isopropyl-2,5-dihydro-1H-pyrrole (CAS 142651-63-6)
- tert-Butyl (2-(4-bromophenyl)-2-oxoethyl)carbamate (CAS 339185-70-5)
- 2-[(Piperidine-1-sulfonyl)methyl]benzonitrile (CAS 1041515-38-1)
- 1-[1-(4-bromophenyl)cyclopropyl]ethan-1-amine hydrochloride (CAS 1417636-05-5)
- 1-[4-(4-chloro-1H-pyrazol-1-yl)-3-fluorophenyl]ethan-1-amine (CAS 1178482-37-5)
- Tirzepatide Impurity 43 (CAS CATO-C4X-324043)
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