4-Amino-3-(difluoromethyl)-5-methoxypicolinoyl chloride CAS 1804679-64-8
| CAS No. | 1804679-64-8 |
| Molecular Formula | C8H7ClF2N2O2 |
| Molecular Weight | 236.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-Amino-3-(difluoromethyl)-5-methoxypicolinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-Amino-3-(difluoromethyl)-5-methoxypicolinoyl chloride (CAS 1804679-64-8), molecular formula C8H7ClF2N2O2 and molecular weight 236.60 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H7ClF2N2O2, 4-Amino-3-(difluoromethyl)-5-methoxypicolinoyl chloride contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 236.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2N2O2 |
| Molecular Weight | 236.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-(2-Amino-5-chloro-3-(difluoromethyl)pyridin-4-yl)acetic acid (CAS 1804451-97-5)
- 2-Amino-6-(chloromethyl)-5-(difluoromethyl)nicotinic acid (CAS 1804462-37-0)
- 4-Amino-6-(difluoromethyl)-5-methoxynicotinoyl chloride (CAS 1804679-00-2)
- 4-Amino-2-(difluoromethyl)-6-methoxynicotinoyl chloride (CAS 1804679-10-4)
- 2-(6-Amino-5-chloro-3-(difluoromethyl)pyridin-2-yl)acetic acid (CAS 1804699-95-3)
- 6-Amino-5-(chloromethyl)-4-(difluoromethyl)nicotinic acid (CAS 1804722-66-4)
- 2-(4-Amino-6-chloro-2-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1804946-32-4)
- 6-Amino-5-(chloromethyl)-4-(difluoromethyl)picolinic acid (CAS 1805013-73-3)
Recommended Standards
- 2-(Aminomethyl)-3-chloro-6-(difluoromethyl)pyridine-4-carboxylic acid (CAS 1804854-33-8)
- 4-(Difluoromethoxy)-3-methoxybenzoyl chloride (CAS 162401-79-8)
- 2-(4-Chloro-3-methoxyphenyl)-2,2-difluoroacetic acid (CAS 1540654-98-5)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-methyl-4-nitropyridine (CAS 1805066-19-6)
- Ethyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate (CAS 1053656-54-4)
- 3-(Chloromethyl)-5-(methoxymethyl)isoxazole (CAS 167155-52-4)
- 4,4'-(Anthracene-9,10-diyl)dibenzoic acid (CAS 42824-53-3)
- N-(5-chloro-2-methoxyphenyl)-2-cyanoacetamide (CAS 63631-10-7)
- 1,4-Bis(9-phenyl-1,10-phenanthrolin-2-yl)benzene (CAS 767319-03-9)
- 4-[2-(2-methylindol-1-yl)ethyl]morpholine (CAS 103608-37-3)
- Propylglycine (CAS 25303-14-4)
- 2-Ethoxypropanehydrazide hydrochloride (CAS 1049750-01-7)
- 2-(2-Neopentylbenzo[d]oxazol-5-yl)acetic acid (CAS 257632-90-9)
- Tirzepatide Impurity 22 X TFA Salt (CAS CATO-C4X-324022)
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