2-(2-Bromo-5-(difluoromethyl)-6-fluoropyridin-3-yl)acetic acid CAS 1804852-26-3
| CAS No. | 1804852-26-3 |
| Molecular Formula | C8H5BrF3NO2 |
| Molecular Weight | 284.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2-Bromo-5-(difluoromethyl)-6-fluoropyridin-3-yl)acetic acid.
CATO supplies 2-(2-Bromo-5-(difluoromethyl)-6-fluoropyridin-3-yl)acetic acid (CAS 1804852-26-3), a certified reference material (molecular formula C8H5BrF3NO2, MW 284.03 g/mol) for analytical method development and quality control.
Structurally, 2-(2-Bromo-5-(difluoromethyl)-6-fluoropyridin-3-yl)acetic acid (C8H5BrF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 284.03 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(2-Bromo-5-(difluoromethyl)-6-fluoropyridin-3-yl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrF3NO2 |
| Molecular Weight | 284.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- Methyl 5-bromo-6-(trifluoromethyl)nicotinate (CAS 1198016-45-3)
- Methyl 3-bromo-5-(trifluoromethyl)picolinate (CAS 1211536-14-9)
- 3-Bromo-6-(trifluoromethyl)pyridine-2-carboxylic Acid Methyl Ester (CAS 1211538-62-3)
- Methyl 4-bromo-6-(trifluoromethyl)picolinate (CAS 1211579-71-3)
- Methyl 5-Bromo-2-(trifluoromethyl)isonicotinate (CAS 1211589-41-1)
- 3-Bromo-5-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214323-86-0)
- Methyl 5-Bromo-3-(trifluoromethyl)pyridine-2-carboxylate (CAS 1214328-84-3)
- 3-Bromo-6-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214374-35-2)
Recommended Standards
- 2-(6-Bromo-4-(difluoromethyl)-5-fluoropyridin-2-yl)acetic acid (CAS 1804639-33-5)
- 4-Bromo-3-(difluoromethyl)-2-fluoropyridine-5-acetic acid (CAS 1804852-40-1)
- 1-(Bromomethyl)-3-nitro-5-(trifluoromethyl)benzene (CAS 180146-67-2)
- 2-(4-Bromo-6-(difluoromethyl)-5-fluoropyridin-3-yl)acetic acid (CAS 1804884-27-2)
- Chenodeoxycholic Acid-3-β-D-glucuronide (CAS 58814-71-4)
- 4-(Dipropylamino)-N-(5-phenyl-1,3,4-oxadiazol-2-yl)butanamide (CAS 89758-26-9)
- Methyl (4,6-dimethylpyrimidin-2-yl)carbamate (CAS 90139-97-2)
- 2,9-Dioxa-6-azaspiro[4.5]decane (CAS 1251712-84-1)
- 5-((1H-Indol-3-yl)methylene)-2-thioxothiazolidin-4-one (CAS 73855-59-1)
- 1-(6-Fluoropyridin-3-yl)cyclopropane-1-carboxylic acid (CAS 1427010-46-5)
- Boc-Gln-Arg-Arg-AMC (CAS 109376-05-8)
- 5-Bromo-2-((2-chlorobenzyl)oxy)benzonitrile (CAS 929450-83-9)
- 4-[(2,2-difluoroethane)sulfonyl]benzoic acid (CAS 1178294-42-2)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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