6-Bromo-4-(difluoromethyl)-5-hydroxypicolinonitrile CAS 1805009-85-1
| CAS No. | 1805009-85-1 |
| Molecular Formula | C7H3BrF2N2O |
| Molecular Weight | 249.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Bromo-4-(difluoromethyl)-5-hydroxypicolinonitrile (CAS 1805009-85-1), molecular formula C7H3BrF2N2O and molecular weight 249.01 g/mol, is a CATO reference standard with documented purity and traceability.
6-Bromo-4-(difluoromethyl)-5-hydroxypicolinonitrile (C7H3BrF2N2O) contains an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3BrF2N2O |
| Molecular Weight | 249.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 5-Bromo-3,3-difluoro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one (CAS 1393540-54-9)
- 2-Bromo-5-(difluoromethyl)-3-hydroxyisonicotinonitrile (CAS 1805009-61-3)
- 4-Bromo-3-cyano-2-(difluoromethyl)-6-hydroxypyridine (CAS 1805010-18-7)
- 2-Bromo-5-(difluoromethyl)-4-hydroxynicotinonitrile (CAS 1805229-39-3)
- 2-Bromo-5-(difluoromethyl)-6-hydroxynicotinonitrile (CAS 1805229-45-1)
- 6-Bromo-3-(difluoromethyl)-5-hydroxypicolinonitrile (CAS 1805229-77-9)
- 2-Bromo-3-(difluoromethyl)-6-hydroxyisonicotinonitrile (CAS 1805437-65-3)
- 6-Bromo-5-(difluoromethyl)-4-hydroxypicolinonitrile (CAS 1805437-86-8)
Recommended Standards
- 5-Iodonicotinic acid (CAS 15366-65-1)
- 6-iodopyridine-3-carboxylic acid (CAS 13054-02-9)
- 2-Hydroxy-6-iodoisonicotinaldehyde (CAS 1289265-35-5)
- 3-Hydroxy-2-iodoisonicotinaldehyde (CAS 1289123-27-8)
- 4-[2-(3-Chlorophenyl)-2-oxoethyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS 626226-02-6)
- 2-(3-Fluorophenoxy)-4-methylaniline (CAS 946716-39-8)
- 9-bromonon-1-yne (CAS 1427729-58-5)
- 5-Amino-1-(3-chloro-2-methylphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1416344-69-8)
- Ethyl 2-hydroxy-2-(pyridin-3-yl)acetate (CAS 17604-75-0)
- (4-Bromophenyl)(2-(piperidin-1-ylmethyl)phenyl)methanone (CAS 898773-06-3)
- Methyl 5-methyl-6-(propylamino)nicotinate (CAS 1355215-22-3)
- (S)-3-Methyl-6-((S)-6-methylhept-5-en-2-yl)cyclohex-2-en-1-one (CAS 61432-71-1)
- 8-Methylsulfonyl-3,8-diazabicyclo[3.2.1]octane (CAS 1219080-99-5)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
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