2-(Chloromethyl)-5-(difluoromethyl)-3-fluoro-6-iodopyridine CAS 1805047-77-1
| CAS No. | 1805047-77-1 |
| Molecular Formula | C7H4ClF3IN |
| Molecular Weight | 321.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Chloromethyl)-5-(difluoromethyl)-3-fluoro-6-iodopyridine (CAS 1805047-77-1), molecular formula C7H4ClF3IN and molecular weight 321.47 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Chloromethyl)-5-(difluoromethyl)-3-fluoro-6-iodopyridine (C7H4ClF3IN) contains a nitrile group, fluorine/chlorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(Chloromethyl)-5-(difluoromethyl)-3-fluoro-6-iodopyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3IN |
| Molecular Weight | 321.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 4-(Chloromethyl)-2-iodo-6-(trifluoromethyl)pyridine (CAS 1393531-85-5)
- 2-(Chloromethyl)-6-iodo-4-(trifluoromethyl)pyridine (CAS 1393570-53-0)
- 2-(Chloromethyl)-3-(difluoromethyl)-5-fluoro-6-iodopyridine (CAS 1804501-32-3)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-fluoro-5-iodopyridine (CAS 1805481-67-7)
- 2-(Chloromethyl)-5-(difluoromethyl)-6-fluoro-3-iodopyridine (CAS 1805481-76-8)
- 2-(Chloromethyl)-3-(difluoromethyl)-4-fluoro-6-iodopyridine (CAS 1805565-50-7)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-fluoro-4-iodopyridine (CAS 1805565-52-9)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-fluoro-3-iodopyridine (CAS 1805578-17-9)
Recommended Standards
- 2-Chloro-4-iodo-6-(trifluoromethyl)aniline (CAS 1314987-33-1)
- 2-Chloro-6-iodo-4-(trifluoromethyl)aniline (CAS 1065102-88-6)
- Nemonoxacin impurity 49 (CAS CATO-C4X-312849)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-fluoro-4-iodopyridine (CAS 1805578-21-5)
- 1-Bromo-4-fluoro-2,3-dihydro-1h-indene (CAS 1188171-96-1)
- 3-((2,6-Dichlorobenzyl)thio)-N-(p-tolyl)thiophene-2-carboxamide (CAS 251096-90-9)
- tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-(chlorosulfonyl)phenyl)propanoate (CAS 2396772-24-8)
- 1-(2,6-difluoro-4-nitrophenyl)-4,4-difluoropiperidine (CAS 2102410-23-9)
- 3-Hydroxy-2-(trifluoromethoxy)benzonitrile (CAS 1261650-71-8)
- 2-Methyldecahydroisoquinoline (CAS 23994-18-5)
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- 1-Pivaloylpiperidine-4-carbonitrile (CAS 1176520-54-9)
- Ethyl 4-(pyrimidin-2-ylamino)benzoate (CAS 959928-89-3)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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