2-(Difluoromethyl)-3-methoxy-6-(trifluoromethyl)pyridine-4-acetic acid CAS 1805151-63-6
| CAS No. | 1805151-63-6 |
| Molecular Formula | C10H8F5NO3 |
| Molecular Weight | 285.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-(Difluoromethyl)-3-methoxy-6-(trifluoromethyl)pyridine-4-acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-(Difluoromethyl)-3-methoxy-6-(trifluoromethyl)pyridine-4-acetic acid (CAS 1805151-63-6) is a high-purity analytical reference standard with the molecular formula C10H8F5NO3 and a molecular weight of 285.17 g/mol.
The molecular framework of 2-(Difluoromethyl)-3-methoxy-6-(trifluoromethyl)pyridine-4-acetic acid (C10H8F5NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H8F5NO3 |
| Molecular Weight | 285.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-6-methoxy-5-(trifluoromethyl)pyridine-3-acetic acid (CAS 1805128-00-0)
- 2-(Difluoromethyl)-4-methoxy-5-(trifluoromethyl)pyridine-3-acetic acid (CAS 1805265-58-0)
- 2-(4-(Difluoromethyl)-5-methoxy-6-(trifluoromethyl)pyridin-2-yl)acetic acid (CAS 1805266-42-5)
- 2-(Difluoromethyl)-4-methoxy-3-(trifluoromethyl)pyridine-6-acetic acid (CAS 1805439-83-1)
- 2-(4-(Difluoromethyl)-3-methoxy-5-(trifluoromethyl)pyridin-2-yl)acetic acid (CAS 1805440-06-5)
- 2-(Difluoromethyl)-3-methoxy-6-(trifluoromethyl)pyridine-5-acetic acid (CAS 1805464-25-8)
- 2-(4-(Difluoromethyl)-5-methoxy-2-(trifluoromethyl)pyridin-3-yl)acetic acid (CAS 1805464-82-7)
- 2-(4-(Difluoromethyl)-6-methoxy-5-(trifluoromethyl)pyridin-3-yl)acetic acid (CAS 1805557-30-5)
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