2-(Difluoromethyl)-5-nitropyridin-4-amine CAS 1805173-38-9
| CAS No. | 1805173-38-9 |
| Molecular Formula | C6H5F2N3O2 |
| Molecular Weight | 189.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Difluoromethyl)-5-nitropyridin-4-amine.
2-(Difluoromethyl)-5-nitropyridin-4-amine (CAS 1805173-38-9) is a high-purity analytical reference standard with the molecular formula C6H5F2N3O2 and a molecular weight of 189.12 g/mol.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-(Difluoromethyl)-5-nitropyridin-4-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 189.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Difluoromethyl)-5-nitropyridin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5F2N3O2 |
| Molecular Weight | 189.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1129458-32-7)
- 2-(Difluoromethyl)-5-hydroxypyridine-3-carboxylic acid (CAS 1256808-21-5)
- 2-(Difluoromethyl)-5-nitrophenol (CAS 1261442-16-3)
- 4-(Difluoromethyl)-2-nitrophenol (CAS 1261649-72-2)
- 4-(Difluoromethyl)-3-nitrophenol (CAS 1261649-77-7)
- 2-(Difluoromethyl)-4-nitrophenol (CAS 1261745-79-2)
- 1-(Difluoromethyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid (CAS 1263177-68-9)
- 2-(Difluoromethyl)-3-nitropyridin-4-amine (CAS 1804439-45-9)
Recommended Standards
- 6-(Difluoromethyl)-4-nitropyridin-2-amine (CAS 1805167-46-7)
- 3-(Difluoromethyl)-4-nitropyridin-2-amine (CAS 1805194-62-0)
- 4-(Difluoromethyl)-5,6-dihydroxypicolinaldehyde (CAS 1805052-71-4)
- 4-(Difluoromethyl)-3-nitropyridin-2-amine (CAS 1805301-92-1)
- 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide (CAS CATO-CCPD103645)
- (2-fluoro-4-methylphenyl)methanesulfonamide (CAS 1565321-68-7)
- 4,6-Diaminoisophthalic acid (CAS 13324-94-2)
- 4-(Aminomethyl)-3-cyano-5-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS 1805586-97-3)
- tert-butyl 1-fluoro-3-oxo-cyclobutanecarboxylate (CAS 2231676-34-7)
- 7-Chloro-4-fluoro-3-iodo-1H-indazole (CAS 1000342-09-5)
- Ethyl 2-(2-chloroacetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 60442-34-4)
- trans-2-[2-(4-Methoxyphenyl)-2-oxoethyl]-cyclohexane-1-carboxylic acid (CAS 735274-77-8)
- Tributyltin iodide (CAS 7342-47-4)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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