2-Chloro-5-(chloromethyl)-6-(difluoromethyl)-3-methoxypyridine CAS 1805181-76-3
| CAS No. | 1805181-76-3 |
| Molecular Formula | C8H7Cl2F2NO |
| Molecular Weight | 242.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 2-Chloro-5-(chloromethyl)-6-(difluoromethyl)-3-methoxypyridine (C8H7Cl2F2NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 242.05 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-Chloro-5-(chloromethyl)-6-(difluoromethyl)-3-methoxypyridine (CAS 1805181-76-3), a certified reference material (molecular formula C8H7Cl2F2NO, MW 242.05 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2F2NO |
| Molecular Weight | 242.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-3-(chloromethyl)-5-(difluoromethyl)-4-methoxypyridine (CAS 1804664-14-9)
- (6-Chloro-5-(chloromethyl)-4-(difluoromethyl)pyridin-2-yl)methanol (CAS 1804857-91-7)
- (2-Chloro-6-(chloromethyl)-4-(difluoromethyl)pyridin-3-yl)methanol (CAS 1804857-98-4)
- (2-Chloro-3-(chloromethyl)-6-(difluoromethyl)pyridin-4-yl)methanol (CAS 1805175-41-0)
- 2-Chloro-5-(chloromethyl)-3-(difluoromethyl)-4-methoxypyridine (CAS 1805181-68-3)
- (6-Chloro-2-(chloromethyl)-5-(difluoromethyl)pyridin-3-yl)methanol (CAS 1805382-18-6)
- (2-Chloro-5-(chloromethyl)-4-(difluoromethyl)pyridin-3-yl)methanol (CAS 1805420-78-3)
- 2-Chloro-3-(chloromethyl)-6-(difluoromethyl)-4-methoxypyridine (CAS 1806019-92-0)
Recommended Standards
- 2,4-Dichloro-6-(difluoromethoxy)benzylamine (CAS 1804883-64-4)
- 2,4-Dichloro-3-(difluoromethoxy)benzylamine (CAS 1806350-32-2)
- 3,4-Dichloro-5-(difluoromethoxy)benzylamine (CAS 1806350-45-7)
- 2,5-Dichloro-4-(difluoromethoxy)benzylamine (CAS 1806353-12-7)
- Methyl 4-bromo-2-methyl-1H-indole-6-carboxylate (CAS 1260383-49-0)
- (R)-Methyl 4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3-acetoxy-12-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (CAS 27240-83-1)
- 1,13-Dioxa-4,7,10,16,19,22-hexaazacyclotetracosane Hexahydrochloride (CAS 126875-53-4)
- 1314446-37-1 6,7-Dichloro-2-(1H-indol-3-yl)-quinoxaline (CAS 1314446-37-1)
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- prop-2-en-1-yl 5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxylate (CAS 1803580-74-6)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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