5-(Difluoromethyl)-6-formyl-3-hydroxypicolinonitrile CAS 1805282-10-3
| CAS No. | 1805282-10-3 |
| Molecular Formula | C8H4F2N2O2 |
| Molecular Weight | 198.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Difluoromethyl)-6-formyl-3-hydroxypicolinonitrile is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Difluoromethyl)-6-formyl-3-hydroxypicolinonitrile (CAS 1805282-10-3), molecular formula C8H4F2N2O2 and molecular weight 198.13 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-(Difluoromethyl)-6-formyl-3-hydroxypicolinonitrile (C8H4F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 198.13 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-(Difluoromethyl)-6-formyl-3-hydroxypicolinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F2N2O2 |
| Molecular Weight | 198.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 6-(Difluoromethyl)-3-formyl-2-hydroxyisonicotinonitrile (CAS 1805921-01-0)
- 3-(Difluoromethyl)-4-formyl-6-hydroxypicolinonitrile (CAS 1806876-34-5)
- 3-(Difluoromethyl)-6-formyl-4-hydroxypicolinonitrile (CAS 1806986-87-7)
- 3-(Difluoromethyl)-5-formyl-2-hydroxyisonicotinonitrile (CAS 1807151-72-9)
- 4-(Difluoromethyl)-3-nitrobenzonitrile (CAS 1956334-79-4)
- (E)-3-(4-(Difluoromethyl)phenyl)acrylic acid (CAS 1240259-30-6)
- 7-(Difluoromethyl)-7,8-dihydroquinazolin-5(6H)-one (CAS 1706446-24-3)
- 5-(Difluoromethyl)-4-methoxy-3-methylpicolinonitrile (CAS 1804371-48-9)
Recommended Standards
- 2,4-Difluoro-6-nitrophenylacetonitrile (CAS 1804517-53-0)
- 2-Cyano-6-(difluoromethyl)isonicotinic acid (CAS 1805647-65-7)
- Methyl 5-hydroxy-6-nitropicolinate (CAS 1803831-69-7)
- 4-Cyano-5-(difluoromethyl)picolinic acid (CAS 1805666-49-2)
- 2-amino-N,N,5-trimethylbenzamide (CAS 178672-23-6)
- 1-(2-Amino-1-(3-phenoxyphenyl)ethyl)pyrrolidine-3-carboxylic acid (CAS 886363-87-7)
- 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile (CAS 120118-14-1)
- 2-(2-(Butylamino)pyridin-3-yl)pyrrolidine-1-carbaldehyde (CAS 1352501-07-5)
- Irinotecan Impurity 65 (CAS CATO-C4X-166765)
- spiro[3.3]heptan-2-one (CAS 30152-57-9)
- [(3Ar,5r,6s,6ar)-6-Hydroxy-2,2-dimethyl-tetrahydro-2h-furo[2,3-d][1,3]dioxol-5-yl]methyl acetate (CAS 80244-96-8)
- tert-Butyl 2-(((5-allylpyridin-3-yl)oxy)methyl)azetidine-1-carboxylate (CAS 1311254-61-1)
- Ibrutinib Impurity 171 (CAS CATO-C4X-1064171)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
Why CATO?
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