4-Cyano-5-(difluoromethyl)picolinic acid CAS 1805666-49-2

Description

The occurrence of 4-Cyano-5-(difluoromethyl)picolinic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-Cyano-5-(difluoromethyl)picolinic acid (CAS 1805666-49-2), molecular formula C8H4F2N2O2 and molecular weight 198.13 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4-Cyano-5-(difluoromethyl)picolinic acid (C8H4F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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