4-(Difluoromethyl)-2-nitro-5-(trifluoromethoxy)pyridine-3-sulfonyl chloride CAS 1805300-88-2
| CAS No. | 1805300-88-2 |
| Molecular Formula | C7H2ClF5N2O5S |
| Molecular Weight | 356.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Difluoromethyl)-2-nitro-5-(trifluoromethoxy)pyridine-3-sulfonyl chloride is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-(Difluoromethyl)-2-nitro-5-(trifluoromethoxy)pyridine-3-sulfonyl chloride (CAS 1805300-88-2), a certified reference material (molecular formula C7H2ClF5N2O5S, MW 356.61 g/mol) for analytical method development and quality control.
The molecular framework of 4-(Difluoromethyl)-2-nitro-5-(trifluoromethoxy)pyridine-3-sulfonyl chloride (C7H2ClF5N2O5S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H2ClF5N2O5S |
| Molecular Weight | 356.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-4-nitro-3-(trifluoromethoxy)pyridine-6-sulfonyl chloride (CAS 1805218-94-3)
- 2-(Difluoromethyl)-4-nitro-3-(trifluoromethoxy)pyridine-5-sulfonyl chloride (CAS 1805300-68-8)
- 2-(Difluoromethyl)-3-nitro-4-(trifluoromethoxy)pyridine-5-sulfonyl chloride (CAS 1806061-07-3)
- 2-(Difluoromethyl)-3-nitro-6-(trifluoromethoxy)pyridine-4-sulfonyl chloride (CAS 1806061-11-9)
- 2-(Difluoromethyl)-5-nitro-3-(trifluoromethoxy)pyridine-4-sulfonyl chloride (CAS 1806061-24-4)
- 4-(Difluoromethyl)-3-nitro-5-(trifluoromethoxy)pyridine-2-sulfonyl chloride (CAS 1806758-44-0)
- 4-(Difluoromethyl)-3'-(trifluoromethoxy)-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1261654-03-8)
- 2-(4-(Difluoromethyl)-6-iodo-5-nitropyridin-3-yl)acetic acid (CAS 1804863-17-9)
Recommended Standards
- 6'-Bromo-8'-chloro-1',5'-dioxo-1',5'-dihydro-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-4-carbonitrile (CAS 1849593-46-9)
- Minodronic Impurity 23 (CAS CATO-C4X-124123)
- Empagliflozin impurity 245 (CAS CATO-C4X-1065245)
- N-(5-bromo-2-chloropyridin-3-yl)morpholine-4-sulfonamide (CAS 1162680-93-4)
- N2-Acetyl-L-lysyl-L-isoleucyl-L-phenylalanyl-L-methionyl-L-lysinamide (CAS 156162-44-6)
- N-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridine-4-carboxamide (CAS 5588-11-4)
- 1-[2-Chloro-4-methyl-5-(methylsulfonyl)phenyl]-4-{[6-(trifluoromethyl)-3-pyridinyl]methyl}piperazine (CAS 909666-43-9)
- (3aS,8aS)-2,2-Dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine 6-oxide (CAS 1817760-50-1)
- 4,6-Bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine (CAS 86789-15-3)
- 4-(Difluoromethyl)-3-methyl-2H-pyrazolo[3,4-b]pyridin-6-ol (CAS 1018047-67-0)
- 5-Bromo-N-methyl-N-((tetrahydrofuran-3-yl)methyl)pyridin-2-amine (CAS 1423378-97-5)
- 2-methoxy-1,3,4-thiadiazole,HCl (CAS 84353-02-6)
- 3-(Pyrrolidin-1-yl)isonicotinic acid (CAS 1257901-68-0)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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