(4-Amino-6-(difluoromethyl)-5-nitropyridin-2-yl)methanol CAS 1805367-99-0
| CAS No. | 1805367-99-0 |
| Molecular Formula | C7H7F2N3O3 |
| Molecular Weight | 219.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (4-Amino-6-(difluoromethyl)-5-nitropyridin-2-yl)methanol (CAS 1805367-99-0), a certified reference material (molecular formula C7H7F2N3O3, MW 219.15 g/mol) for analytical method development and quality control.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, (4-Amino-6-(difluoromethyl)-5-nitropyridin-2-yl)methanol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 219.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7F2N3O3 |
| Molecular Weight | 219.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- (4-Amino-2-(difluoromethyl)-5-nitropyridin-3-yl)methanol (CAS 1805220-79-4)
- (4-Amino-3-(difluoromethyl)-5-nitropyridin-2-yl)methanol (CAS 1805354-72-6)
- (2-Amino-6-(difluoromethyl)-5-nitropyridin-3-yl)methanol (CAS 1805992-16-8)
- (6-Amino-5-(difluoromethyl)-4-nitropyridin-3-yl)methanol (CAS 1806890-48-1)
- (2-Amino-6-(difluoromethyl)-4-nitropyridin-3-yl)methanol (CAS 1806890-53-8)
- (6-Amino-4-(difluoromethyl)-5-nitropyridin-3-yl)methanol (CAS 1806902-64-6)
- Methyl 2-Amino-5-(trifluoromethyl)benzoate (CAS 117324-58-0)
- Ethyl 2-amino-3,4,5-trifluorobenzoate (CAS 1184500-46-6)
Recommended Standards
- 4-(Difluoromethyl)-3-methoxy-5-nitropyridin-2-amine (CAS 1805365-32-5)
- 2-(Aminomethyl)-4-(difluoromethyl)-5-hydroxy-3-nitropyridine (CAS 1805536-03-1)
- 3-(Difluoromethyl)-4-methoxy-5-nitropyridin-2-amine (CAS 1805365-10-9)
- 4-(Difluoromethyl)-6-methoxy-3-nitropyridin-2-amine (CAS 1806796-97-3)
- N-Cyclohexyl-2-prop-2-enoxybenzamide (CAS 63887-50-3)
- 2-Amino-N-cyclopropyl-N-(1-methylpyrrolidin-3-yl)acetamide (CAS 1353960-24-3)
- 5-Ethyl-4-(hydroxymethyl)isoxazole-3-carboxylic acid (CAS 1134334-00-1)
- 1-(cyclopropylmethyl)piperidin-4-ol (CAS 63463-44-5)
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