2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride CAS 1805435-09-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1805435-09-9
Molecular FormulaC8H5ClF3NO2
Molecular Weight239.58 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride CAS 1805435-09-9 chemical structure

Description

The occurrence of 2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride (CAS 1805435-09-9), molecular formula C8H5ClF3NO2 and molecular weight 239.58 g/mol, is a CATO reference standard with documented purity and traceability.

2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride (C8H5ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures 2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC8H5ClF3NO2
Molecular Weight239.58 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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