4-(Difluoromethyl)-6-fluoro-2-methoxynicotinoyl chloride CAS 1805461-73-7
| CAS No. | 1805461-73-7 |
| Molecular Formula | C8H5ClF3NO2 |
| Molecular Weight | 239.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-fluoro-2-methoxynicotinoyl chloride.
4-(Difluoromethyl)-6-fluoro-2-methoxynicotinoyl chloride (CAS 1805461-73-7) is a high-purity analytical reference standard with the molecular formula C8H5ClF3NO2 and a molecular weight of 239.58 g/mol.
Based on its molecular formula C8H5ClF3NO2, 4-(Difluoromethyl)-6-fluoro-2-methoxynicotinoyl chloride contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 239.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Difluoromethyl)-6-fluoro-2-methoxynicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF3NO2 |
| Molecular Weight | 239.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-3-fluoro-5-methoxypyridine-6-carbonyl chloride (CAS 1804951-42-5)
- 2-(Difluoromethyl)-3-fluoro-6-methoxypyridine-4-carbonyl chloride (CAS 1805176-06-0)
- 2-(Difluoromethyl)-5-fluoro-3-methoxypyridine-4-carbonyl chloride (CAS 1805434-91-6)
- 2-(Difluoromethyl)-5-fluoro-4-methoxypyridine-3-carbonyl chloride (CAS 1805434-99-4)
- 2-(Difluoromethyl)-6-fluoro-4-methoxypyridine-3-carbonyl chloride (CAS 1805435-09-9)
- 2-(Difluoromethyl)-6-fluoro-5-methoxypyridine-3-carbonyl chloride (CAS 1805435-14-6)
- 4-(Difluoromethyl)-2-fluoro-5-methoxynicotinoyl chloride (CAS 1805527-38-1)
- 2-(Difluoromethyl)-4-fluoro-3-methoxypyridine-6-carbonyl chloride (CAS 1805605-94-0)
Recommended Standards
- 3-Amino-4-chloro-5-(trifluoromethyl)benzoic acid (CAS 1805446-41-6)
- 2-(Chloromethyl)-3-(difluoromethyl)-6-fluoropyridine-4-carboxylic acid (CAS 1805445-81-1)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-fluoropyridine-3-carboxylic acid (CAS 1805527-76-7)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-fluoropyridine-5-carboxylic acid (CAS 1805604-38-9)
- Ethynyl(triphenylphosphine)gold (CAS 91071-10-2)
- (S)-1,1,1-trifluoroheptan-2-ol (CAS 130025-35-3)
- 2-Bromo-5-(difluoromethyl)pyridin-4-ol (CAS 1805314-69-5)
- 7-Fluorochromane-4-carboxylic acid (CAS 1202889-73-3)
- 3,4-Dimethyl-1H-pyrrole (CAS 822-51-5)
- 2-(Tert-butyl)-1H-indole-5-carbaldehyde (CAS 1557706-98-5)
- 3-(4-(Aminomethyl)phenyl)-1,3-oxazinan-2-one (CAS 1247674-71-0)
- 6-Thioxo-1,6-dihydropyridazin-3(2H)-one (CAS 52786-73-9)
- 3-Fluoro-5-morpholinobenzoic acid (CAS 295311-40-9)
- Insulin Glulisine (CAS 207748-29-6)
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