3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile CAS 1805973-57-2
| CAS No. | 1805973-57-2 |
| Molecular Formula | C9H4F2N4O2 |
| Molecular Weight | 238.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile.
3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile (CAS 1805973-57-2) is a high-purity analytical reference standard with the molecular formula C9H4F2N4O2 and a molecular weight of 238.15 g/mol.
3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile (C9H4F2N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H4F2N4O2 |
| Molecular Weight | 238.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Cyanomethyl Standards
- 5-(Cyanomethyl)-3-(difluoromethyl)-4-nitropicolinonitrile (CAS 1805288-78-1)
- 5-(Cyanomethyl)-4-(difluoromethyl)-3-nitropicolinonitrile (CAS 1805288-85-0)
- N-(4-((cyanomethyl)sulfonyl)phenyl)acetamide (CAS 90915-78-9)
- (4-Cyanomethyl)-cyclohexyl-carbamic acid tert-butyl ester (CAS 1403764-79-3)
- 4'-(Cyanomethyl)[1,1'-biphenyl]-3-carboxylic acid (CAS 893734-46-8)
- 4'-(Cyanomethyl)[1,1'-biphenyl]-4-carboxylic acid (CAS 893734-55-9)
- Methyl 2-((Cyanomethyl)sulfonyl)benzoate (CAS 175137-52-7)
- 1-Benzyl-4-(cyanomethyl)piperidine-4-carbonitrile (CAS 86945-27-9)
Recommended Standards
- 4-Cyano-2-(difluoromethyl)-5-nitropyridine-3-acetonitrile (CAS 1807129-26-5)
- 2-(6-Nitro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)acetic acid (CAS 19739-41-4)
- (4-(Hexylthio)phenyl)boronic acid (CAS 151588-39-5)
- (3-bromoimidazo[2,1-b]thiazol-5-yl)methanamine (CAS 2411100-94-0)
- 5-Ethyl-2,3-dihydrobenzofuran-2-carboxylic acid (CAS 1269535-05-8)
- 2-(((4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-1H-benzo[d]imidazole (CAS 578735-97-4)
- (2s)-3-Amino-2-methylpropan-1-ol (CAS 88586-62-3)
- 2,2,2-Trifluoro-N-(1-(thiophen-2-yl)ethyl)ethan-1-amine (CAS 1016501-33-9)
- 7-Chloro-8-(2-hydroxyethoxy)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 2883421-73-4)
- 4-(3-Bromo-4-fluorophenyl)thiazol-2(3h)-imine (CAS 676348-24-6)
- 2-(2-Acetylphenyl)isonicotinic acid, 97% (CAS 1258633-36-1)
- Diltiazem Impurity 19 (CAS 96739-78-5)
- 6,7-Dihydrobenzo[d]isoxazol-5(4H)-one (CAS 1196151-20-8)
- Peptide 442 (CAS CATO-CPTD788442)
Why CATO?
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