4-Cyano-2-(difluoromethyl)-5-nitropyridine-3-acetonitrile CAS 1807129-26-5
| CAS No. | 1807129-26-5 |
| Molecular Formula | C9H4F2N4O2 |
| Molecular Weight | 238.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Cyano-2-(difluoromethyl)-5-nitropyridine-3-acetonitrile (CAS 1807129-26-5) is a high-purity analytical reference standard with the molecular formula C9H4F2N4O2 and a molecular weight of 238.15 g/mol.
4-Cyano-2-(difluoromethyl)-5-nitropyridine-3-acetonitrile (C9H4F2N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-Cyano-2-(difluoromethyl)-5-nitropyridine-3-acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H4F2N4O2 |
| Molecular Weight | 238.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 3-(Cyanomethyl)-5-(difluoromethyl)-4-nitropicolinonitrile (CAS 1805973-57-2)
- 2-(6-Nitro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)acetic acid (CAS 19739-41-4)
- 5-(Cyanomethyl)-4-(difluoromethyl)-3-nitropicolinonitrile (CAS 1805288-85-0)
- (3-bromoimidazo[2,1-b]thiazol-5-yl)methanamine (CAS 2411100-94-0)
- 4-[(2-methoxyphenyl)(methyl)sulfamoyl]benzoic acid (CAS 379255-57-9)
- (S)-4-Amino-5,5,5-trifluoropentanoic acid (CAS 1287373-66-3)
- 2-((4-Fluorophenyl)thio)-1-morpholinoethan-1-one (CAS 339097-77-7)
- N-(1H-Benzo[d]imidazol-1-yl)propionamide (CAS 40995-19-5)
- 1-(3,4-Dichlorophenyl)propan-1-amine (CAS 40023-89-0)
- 2-(3-Fluoropiperidin-1-yl)ethan-1-amine (CAS 477577-23-4)
- 4-[3-(trifluoromethyl)benzoyl]pyridine (CAS 61977-56-8)
- 4-(tert-Butyl)-3-hydroxy-N,N-dimethylbenzamide (CAS 1243367-39-6)
- Memantine Impurity 68 (CAS CATO-C4X-105868)
- TAT 14 Peptide (Nrf2 Activator III) (CAS 1362661-34-4)
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