2-Chloro-6-(difluoromethyl)-5-hydroxypyridine-3-sulfonamide CAS 1806004-06-7
| CAS No. | 1806004-06-7 |
| Molecular Formula | C6H5ClF2N2O3S |
| Molecular Weight | 258.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-6-(difluoromethyl)-5-hydroxypyridine-3-sulfonamide.
CATO supplies 2-Chloro-6-(difluoromethyl)-5-hydroxypyridine-3-sulfonamide (CAS 1806004-06-7), a certified reference material (molecular formula C6H5ClF2N2O3S, MW 258.63 g/mol) for analytical method development and quality control.
Structurally, 2-Chloro-6-(difluoromethyl)-5-hydroxypyridine-3-sulfonamide (C6H5ClF2N2O3S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 258.63 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5ClF2N2O3S |
| Molecular Weight | 258.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-Chloro-2-(pyridin-3-yl)-5-(trifluoromethyl)pyridine (CAS 1214324-38-5)
- 2-Chloro-3-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214347-45-1)
- 2-Chloro-3-(pyridin-4-yl)-6-(trifluoromethyl)pyridine (CAS 1214355-04-0)
- 3-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214356-58-7)
- 3-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyridine (CAS 1214366-95-6)
- 2-Chloro-3-(pyridin-4-yl)-5-(trifluoromethyl)pyridine (CAS 1214366-98-9)
- 3-Chloro-2-(pyridin-4-yl)-5-(trifluoromethyl)pyridine (CAS 1214370-11-2)
- 2-Chloro-3-(pyridin-3-yl)-5-(trifluoromethyl)pyridine (CAS 1214370-14-5)
Recommended Standards
- 2-Chloro-4-(difluoromethyl)-6-hydroxypyridine-3-sulfonamide (CAS 1805407-25-3)
- 4-Chloro-5-(difluoromethyl)-3-hydroxypyridine-2-sulfonamide (CAS 1806004-31-8)
- 4-Amino-2-(difluoromethyl)-6-hydroxypyridine-3-sulfonyl chloride (CAS 1805330-81-7)
- 4-Amino-6-(difluoromethyl)-5-hydroxypyridine-2-sulfonyl chloride (CAS 1806883-02-2)
- 3-Bromo-5-propoxybenzoic acid (CAS 1226808-68-9)
- 2,3-Dihydro-5-benzofuranacetic Acid-d2 Methyl Ester (CAS 1219153-23-7)
- 5-Iodo-2-((2-methylcyclobutyl)methoxy)pyridine (CAS 1710301-90-8)
- 5-Chloro-2-methylpyridine hydrate (CAS 1881288-70-5)
- 4-Bromo-1-ethyl-N-(2-(tetrahydrofuran-2-yl)ethyl)-1h-pyrrole-2-carboxamide (CAS 1179975-09-7)
- 3-Bromo-4-(methylsulfonyl)pyridine (CAS 1209458-05-8)
- 6,6,6-Trifluorohexan-2-ol (CAS 1535364-59-0)
- 4-Cyclopropylpyrrolidine-3-carboxylic acid (CAS 1342580-34-0)
- 5-Ethyl-1-[2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (CAS 1096934-94-9)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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